Описание: This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases.
Автор: Jorge R. Oksenberg; David Brassat Название: Immunogenetics of Autoimmune Disease ISBN: 1489997482 ISBN-13(EAN): 9781489997487 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
Автор: Herman Friedman; Thomas W. Klein; Steven Specter Название: Drugs of Abuse, Immunity, and Immunodeficiency ISBN: 1468459279 ISBN-13(EAN): 9781468459272 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a symposium held in Clearwater Beach, Florida, December 13--15, 1989
Автор: Ochs, Hans D.; Smith, C. I. Edvard; Puck, Jennifer Название: Primary Immunodeficiency Diseases ISBN: 019514774X ISBN-13(EAN): 9780195147742 Издательство: Oxford Academ Рейтинг: Цена: 19404.00 р. Наличие на складе: Поставка под заказ.
Описание: Presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders - disorders featuring an increased susceptibility to infections and, in, certain conditions, an increased rate of malignancies and autoimmune disorders.
Автор: A.D.B Webster Название: Immunodeficiency and Disease ISBN: 9401070660 ISBN-13(EAN): 9789401070669 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The AIDS epidemic has popularized immune deficiency and has led to a rapid increase in the funding for research into the effect of viruses on immunity. AIDS is an important precedent, and it is likely that other less pathogenic retroviruses will eventually turn dut to cause some of the rarer immunodeficiency disorders in children and adults.
Описание: In this concise book, an international panel of experts provide a succinct, up-to-date, evidence-based reference to the neurological consequences of infectious diseases and immunodeficiency syndromes in children in one readily accessible volume.
Автор: J.A. Madrigal; Tibor N?n?si; Margita Bencov?; Dere Название: Immunogenetics: Advances and Education ISBN: 9401063087 ISBN-13(EAN): 9789401063081 Издательство: Springer Рейтинг: Цена: 32144.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop, held in Casta-Papiernicka, Bratislava, Slovak Republic, September 5-9, 1996
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