Analysis of Carbohydrates by Capillary Electrophoresis, Kevin D. Altria; Aran Paulus; Antje Klockow-Beck

Автор: Christoph Heller; Kevin D. Altria
Название: Analysis of Nucleic Acids by Capillary Electrophoresis
ISBN: 3322910172 ISBN-13(EAN): 9783322910172
Издательство: Springer
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Описание: During the last decade, capillary electrophoresis has been developed into a very powerful analytical technique, which has many advantages over conventional slab gel techniques. The improvement is comparable to the one occuring earlier in the field of chromatography, with the introduction of the high performance technology. How important this technique has be- come, is reflected by the shear volume of papers published each month; as well as a dozen of books already published on this subject. One of the most important conferences in the field, the "International Symposium on High Performance Capillary Electrophoresis" attracts now nearly thousand people every year. As capillary electrophoresis can be applied to many different analytical problems, a spe- cialization is unavoidable. This evolution is also reflected in the development of instrumen- tation: whereas the first devices were designed for all possible applications, new instruments are now built, that are specialized for one particular task, e.g. DNA analysis. I very much welcome the decision of the series editor and the publisher, to edit a series ofspecialized books, covering all aspects of capillary electrophoresis. Having worked on the electrophoretic separation of DNA for many years, I am convinced that there are so many different aspects on this issue that they deserve a whole book on their own. Therefore, I was happy to agree when being asked to edit this book.

Автор: Kevin D. Altria; Kevin D. Altria
Название: Analysis of Pharmaceuticals by Capillary Electrophoresis
ISBN: 3322850137 ISBN-13(EAN): 9783322850133
Издательство: Springer
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Описание: During the 1980's the analysis of pharmaceuticals was dominated by the use of High Perfor- mance Liquid Chromatography (HPLC). Other separative techniques such as Gas Chromato- graphy and Thin Layer Chromatography offered alternatives but their quantitative capabili- ties and/or solute range could not approach that of HPLC. The majority of pharmaceuticals are ionic and it would be reasonable to assume that electrophoresis may be useful in the analysis of pharmaceuticals. However, the electrophore- tic instruments available in the 1980's were labour intensive and employed post-separation detection procedures. During the late 1980's and early 1990's extensive research was con- ducted into the possibilities of conducting electrophoretic separations in capillaries. This approach allowed on-line detection and could be performed on fully automated equipment. This research led to the advent of modern day capillary electrophoresis (CE) instruments which offer similar performance and automation levels to that of HPLC. Research was also focused on developing applications for CE and particular attention was paid to applications within the pharmaceutical analysis area. These applications proved that CE could be applied to a wide range of drug types including water insoluble and neutral compounds. The ability to achieve efficient chiral separations of drugs also increased the popularity of the technique. CE with indirect UV detection has become established as a simple and effective alternative to ion-exchange chromatography for the determination of small inorganic or organic ions.

Автор: Wim Kok
Название: Capillary Electrophoresis: Instrumentation and Operation
ISBN: 3322831353 ISBN-13(EAN): 9783322831354
Издательство: Springer
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Описание: Die Kapillarelektrophorese kann als routinemд ige Analysenmethode in der Praxis eingesetzt werden. Der Autor dieser englischsprachigen Monographie beschreibt alle technischen und praktischen Aspekte, die dabei berьcksichtigt werden mьssen. Aber er geht auch auf neue wissenschaftliche Entwicklungen ein, die noch erforscht werden und sich bis jetzt nicht fьr die Routine eignen. Das Buch spricht - im Gegensatz zu dem Titel von Engelhardt - fortgeschrittenere Leser an.