Histones and Nucleohistones, D. M. Philips

Автор: Shelley L. Berger; O. Nakanishi; Bernhard Haendler
Название: The Histone Code and Beyond
ISBN: 364242175X ISBN-13(EAN): 9783642421754
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin.

Автор: Benoit Guillemette; Luc R. Gaudreau
Название: Histones
ISBN: 1493966286 ISBN-13(EAN): 9781493966288
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume provides a comprehensive list of protocols for molecular biologists, biochemists and geneticists. Chapters cover protocols that further the study into protein complexes that modify chromatin either by adding or removing post-translational modifications, or by exchanging histone variants within the nucleosome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Histones: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Автор: Tso-Pang Yao; Edward Seto
Название: Histone Deacetylases: the Biology and Clinical Implication
ISBN: 3642270859 ISBN-13(EAN): 9783642270857
Издательство: Springer
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Цена: 41925.00 р.
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Описание: The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319181017 ISBN-13(EAN): 9783319181011
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319376667 ISBN-13(EAN): 9783319376660
Издательство: Springer
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Цена: 16977.00 р.
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Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression.