Histone Recognition, Ming-Ming Zhou

Автор: Tso-Pang Yao; Edward Seto
Название: Histone Deacetylases: the Biology and Clinical Implication
ISBN: 3642270859 ISBN-13(EAN): 9783642270857
Издательство: Springer
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Цена: 41925.00 р.
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Описание: The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Автор: Hans-Joachim Anders; Adriana Migliorini
Название: Innate DNA and RNA Recognition
ISBN: 1493945831 ISBN-13(EAN): 9781493945832
Издательство: Springer
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Цена: 14673.00 р.
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Описание:

Part I: Analysis of Viral Nucleic Acid Sensing In-Silico and In-Vitro

1. Detection of RNA Modifications by HPLC Analysis and Competitive ELISA

Gernot Nees, Andreas Kaufmann and Stefan Bauer

2. Enzymatic Synthesis and Purification of a Defined RIG-I Ligand

Marion Goldeck, Martin Schlee, Gunther Hartmann, and Veit Hornung

3. Crystallization of Mouse RIG-I ATPase Domain: In situ Proteolysis

Filiz Civril and Karl-Peter Hopfner

4. Isolation of RIG-I-associated RNAs from Virus Infected Cells

Andreas Schmidt, Andreas Linder, Nicolas Linder, and Simon Rothenfu er

5. Structure Modeling of Toll-like Receptors

Jing Gong and Tiandi Wei

6. Nucleic Acid Recognition in Dendritic Cells

Alexander Heiseke, Katharina Eisenдcher, and Anne Krug

7. Viral Nucleic Acid Recognition in Human Non-immune cells: In vitro Systems

Andrea Ribeiro and Markus Wцrnle

8. Analysis of Nucleic Acid-induced Non-immune Cell Death in Vitro

Simone Romoli, Adriana Migliorini

9. In vitro Analysis of Nucleic Acid Recognition in B Lymphocytes

Saskia Ziegler and Isabelle Bekeredjian-Ding

10. Mapping of Optimal CD8 T Cell Epitopes

Julia Roider, Thomas Vollbrecht and Rika Draenert

11. A Modular Approach to Suppression Ass says: TLR-Ligands, Conditioned Medium, and Viral Infection

Viktor H. Koelzer and David Anz

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319181017 ISBN-13(EAN): 9783319181011
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Автор: Shelley L. Berger; O. Nakanishi; Bernhard Haendler
Название: The Histone Code and Beyond
ISBN: 364242175X ISBN-13(EAN): 9783642421754
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin.

Автор: Benoit Guillemette; Luc R. Gaudreau
Название: Histones
ISBN: 1493966286 ISBN-13(EAN): 9781493966288
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume provides a comprehensive list of protocols for molecular biologists, biochemists and geneticists. Chapters cover protocols that further the study into protein complexes that modify chromatin either by adding or removing post-translational modifications, or by exchanging histone variants within the nucleosome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Histones: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Автор: D. M. Philips
Название: Histones and Nucleohistones
ISBN: 1468418173 ISBN-13(EAN): 9781468418170
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Chapters 1, 2, part of 3, and all of Chapters 5 and 6, cover the occurrence, preparation, characterization, sequence structure, bio- physical properties and finally, the biosynthesis and functions of the histones.

Автор: Paul R. Crocker
Название: Mammalian Carbohydrate Recognition Systems
ISBN: 3642536700 ISBN-13(EAN): 9783642536700
Издательство: Springer
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Цена: 13974.00 р.
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Описание: In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins.

Автор: P. CUATRECASAS AND M. F. GREAVES
Название: Receptors and Recognition
ISBN: 0412152800 ISBN-13(EAN): 9780412152801
Издательство: Springer
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Цена: 12157.00 р.
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Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034807945 ISBN-13(EAN): 9783034807944
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034806876 ISBN-13(EAN): 9783034806879
Издательство: Springer
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Цена: 20896.00 р.
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Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Yogambigai Velmurugu
Название: Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition
ISBN: 3319451286 ISBN-13(EAN): 9783319451282
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.

Автор: Alexander Sigalov
Название: Multichain Immune Recognition Receptor Signaling
ISBN: 1441918876 ISBN-13(EAN): 9781441918871
Издательство: Springer
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Цена: 32004.00 р.
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Описание: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.