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Genomics of Pattern Recognition Receptors, Anton G. Kutikhin; Arseniy E. Yuzhalin


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Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название:  Genomics of Pattern Recognition Receptors
ISBN: 9783034806879
Издательство: Springer
Классификация:





ISBN-10: 3034806876
Обложка/Формат: Hardcover
Страницы: 196
Вес: 0.47 кг.
Дата издания: 10.09.2013
Язык: English
Издание: 2013 ed.
Иллюстрации: Biography
Размер: 234 x 152 x 18
Читательская аудитория: Professional & vocational
Основная тема: Receptors
Подзаголовок: Applications in Oncology and Cardiovascular Diseases
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.


Immune Receptors

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Immunobiology of Natural Killer Cell Receptors

Автор: Vivier Eric, Colonna Marco
Название: Immunobiology of Natural Killer Cell Receptors
ISBN: 3540260838 ISBN-13(EAN): 9783540260837
Издательство: Springer
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Цена: 26122.00 р.
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Описание: Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Endothelin Receptors and Signaling Mechanisms

Автор: David M. Pollock; Robert F. Highsmith
Название: Endothelin Receptors and Signaling Mechanisms
ISBN: 366211674X ISBN-13(EAN): 9783662116746
Издательство: Springer
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Цена: 14365.00 р.
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Cell Surface Receptors

Автор: Lee E. Limbird
Название: Cell Surface Receptors
ISBN: 1475718845 ISBN-13(EAN): 9781475718843
Издательство: Springer
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Цена: 14365.00 р.
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A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

Автор: Borea
Название: A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
ISBN: 904813143X ISBN-13(EAN): 9789048131433
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This book covers the current state of knowledge of the adenosine A3 receptor. Coverage includes data from studies of theoretical, molecular, and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications.

Investigation of Membrane-Located Receptors

Автор: Reid Eric
Название: Investigation of Membrane-Located Receptors
ISBN: 1468446339 ISBN-13(EAN): 9781468446333
Издательство: Springer
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Цена: 16979.00 р.
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Описание: But `Proceedings` are proverbially ephemeral material reflecting an array of solo performances, whereas this book is hopefully more like an orchestra`s performance, of classical together with new material. Related to receptor methodo- logy, receptor features and phenomena get due attention in the text.

Discoidin Domain Receptors in Health and Disease

Автор: Fridman
Название: Discoidin Domain Receptors in Health and Disease
ISBN: 1493963813 ISBN-13(EAN): 9781493963812
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Activating and Inhibitory Immunoglobulin-like Receptors

Автор: M. D. Cooper; T. Takai; J.V. Ravetch
Название: Activating and Inhibitory Immunoglobulin-like Receptors
ISBN: 4431679596 ISBN-13(EAN): 9784431679592
Издательство: Springer
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Цена: 22203.00 р.
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Описание: This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system.

The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

Автор: Jan G.J. Winkel; M. Hogarth
Название: The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity
ISBN: 9401061068 ISBN-13(EAN): 9789401061063
Издательство: Springer
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Цена: 28734.00 р.
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Описание: The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed.

Negative Co-Receptors and Ligands

Автор: Rafi Ahmed; Tasuku Honjo
Название: Negative Co-Receptors and Ligands
ISBN: 3642267777 ISBN-13(EAN): 9783642267772
Издательство: Springer
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Цена: 20896.00 р.
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Описание: For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes these molecules` functions and mechanisms.

Proteases and Their Receptors in Inflammation

Автор: Nathalie Vergnolle; Michel Chignard
Название: Proteases and Their Receptors in Inflammation
ISBN: 3034803427 ISBN-13(EAN): 9783034803427
Издательство: Springer
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Цена: 26120.00 р.
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Описание:

Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response.

This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

"

G Protein-Coupled Receptors: Signaling, Trafficking and Regulatio

Автор: Arun K. Shukla
Название: G Protein-Coupled Receptors: Signaling, Trafficking and Regulatio
ISBN: 0128035951 ISBN-13(EAN): 9780128035955
Издательство: Elsevier Science
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Цена: 21222.00 р.
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Описание:

"G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation," a new volume in the "Methods in Cell Biology" series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation.
Covers the increasingly appreciated cell biology field of G-protein-coupled receptorsIncludes both established and new technologiesContributed by experts in the fieldCovers topics such as signaling, trafficking, and regulation


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