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Genomics of Pattern Recognition Receptors, Anton G. Kutikhin; Arseniy E. Yuzhalin


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Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название:  Genomics of Pattern Recognition Receptors
ISBN: 9783034807944
Издательство: Springer
Классификация:





ISBN-10: 3034807945
Обложка/Формат: Paperback
Страницы: 185
Вес: 0.29 кг.
Дата издания: 26.08.2015
Язык: English
Размер: 234 x 156 x 11
Основная тема: Life Sciences
Подзаголовок: Applications in Oncology and Cardiovascular Diseases
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.


Immune Receptors

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Endotoxins: Structure, Function and Recognition

Автор: Wang
Название: Endotoxins: Structure, Function and Recognition
ISBN: 9400732678 ISBN-13(EAN): 9789400732674
Издательство: Springer
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Цена: 34799.00 р.
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Описание: Endotoxins explores the mechanism behind whole-body inflammation and sepsis by synthesizing the leading research in the field. The biosynthesis, genetic constitution, and structure of endotoxins are presented, in addition to their interaction with host cells.

Histone Recognition

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319181017 ISBN-13(EAN): 9783319181011
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Histone Recognition

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319376667 ISBN-13(EAN): 9783319376660
Издательство: Springer
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Цена: 16977.00 р.
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Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression.

Genomics of Pattern Recognition Receptors

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034806876 ISBN-13(EAN): 9783034806879
Издательство: Springer
Рейтинг:
Цена: 20896.00 р.
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Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Receptors and Recognition

Автор: P. CUATRECASAS AND M. F. GREAVES
Название: Receptors and Recognition
ISBN: 0412152800 ISBN-13(EAN): 9780412152801
Издательство: Springer
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Цена: 12157.00 р.
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Target Pattern Recognition in Innate Immunity

Автор: Uday Kishore
Название: Target Pattern Recognition in Innate Immunity
ISBN: 1461417090 ISBN-13(EAN): 9781461417095
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This volume examines the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events.

Target Pattern Recognition in Innate Immunity

Автор: Uday Kishore
Название: Target Pattern Recognition in Innate Immunity
ISBN: 1441909001 ISBN-13(EAN): 9781441909008
Издательство: Springer
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Цена: 27950.00 р.
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Описание: This volume examines the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events.

Multichain Immune Recognition Receptor Signaling

Автор: Alexander Sigalov
Название: Multichain Immune Recognition Receptor Signaling
ISBN: 1441918876 ISBN-13(EAN): 9781441918871
Издательство: Springer
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Цена: 32004.00 р.
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Описание: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition

Автор: Yogambigai Velmurugu
Название: Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition
ISBN: 3319451286 ISBN-13(EAN): 9783319451282
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.

Recognition of Carbohydrates in Biological Systems, Part A : Gene

Автор: Y. C. Lee
Название: Recognition of Carbohydrates in Biological Systems, Part A : Gene
ISBN: 0121822656 ISBN-13(EAN): 9780121822651
Издательство: Elsevier Science
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Цена: 25054.00 р.
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Описание: Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covs the wide area of methodology of carbohydrate recognition. This volume and its companion, Volume 363, present state-of-the-art methodologies, as well as the most recent biological observations in this area.

Innate DNA and RNA Recognition

Автор: Hans-Joachim Anders; Adriana Migliorini
Название: Innate DNA and RNA Recognition
ISBN: 1493945831 ISBN-13(EAN): 9781493945832
Издательство: Springer
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Цена: 14673.00 р.
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Описание:

Part I: Analysis of Viral Nucleic Acid Sensing In-Silico and In-Vitro

1. Detection of RNA Modifications by HPLC Analysis and Competitive ELISA

Gernot Nees, Andreas Kaufmann and Stefan Bauer

2. Enzymatic Synthesis and Purification of a Defined RIG-I Ligand

Marion Goldeck, Martin Schlee, Gunther Hartmann, and Veit Hornung

3. Crystallization of Mouse RIG-I ATPase Domain: In situ Proteolysis

Filiz Civril and Karl-Peter Hopfner

4. Isolation of RIG-I-associated RNAs from Virus Infected Cells

Andreas Schmidt, Andreas Linder, Nicolas Linder, and Simon Rothenfu er

5. Structure Modeling of Toll-like Receptors

Jing Gong and Tiandi Wei

6. Nucleic Acid Recognition in Dendritic Cells

Alexander Heiseke, Katharina Eisenдcher, and Anne Krug

7. Viral Nucleic Acid Recognition in Human Non-immune cells: In vitro Systems

Andrea Ribeiro and Markus Wцrnle

8. Analysis of Nucleic Acid-induced Non-immune Cell Death in Vitro

Simone Romoli, Adriana Migliorini

9. In vitro Analysis of Nucleic Acid Recognition in B Lymphocytes

Saskia Ziegler and Isabelle Bekeredjian-Ding

10. Mapping of Optimal CD8 T Cell Epitopes

Julia Roider, Thomas Vollbrecht and Rika Draenert

11. A Modular Approach to Suppression Ass says: TLR-Ligands, Conditioned Medium, and Viral Infection

Viktor H. Koelzer and David Anz

12. MicroRNA Methodology: Advances in miRNA-technologies

Theresa Kaeuferle, Sabine Bartel, Stefan Dehmel, and Susanne Krauss-Etschmann

Part II: Analysis of Nucleic Acid Sensing In-Vivo

13. Expression Profiling by Real-time Quantitative Polymerase Chain Reaction (RT-qPCR)

Maciej Lech and Hans-Joachim Anders

14. Evaluating the Role of Nucleic Acid Antigens in Murine Models of Systemic Lupus Erythematosus

Amanda A. Watkins, Ramon G. B. Bonegio and Ian R. Rifkin

15. Induction and Analysis of Nephrotoxic Serum Nephritis in Mice

John M. Hoppe and Volker Vielhauer

16. Isolation of Intratumoral Leukocytes of TLR-stimulated Tumor-bearing Mice

Moritz Rapp, David Anz, and Max Schnurr

17. Bifunctional siRNAs for Tumor Therapy

Fanny Matheis and Robert Besch


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