Calcium Homeostasis, E. Carafoli; J. Krebs

Автор: Jen-Tsan Ashley Chi
Название: Molecular Genetics of Dysregulated pH Homeostasis
ISBN: 1493916823 ISBN-13(EAN): 9781493916825
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.

Автор: Kelly Anne Hyndman; Thomas L. Pannabecker
Название: Sodium and Water Homeostasis
ISBN: 1493932128 ISBN-13(EAN): 9781493932122
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.

Автор: Banfalvi Gaspar
Название: Homeostasis - Tumor - Metastasis
ISBN: 940077334X ISBN-13(EAN): 9789400773349
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.