Jen-Tsan Ashley Chi Molecular Genetics of Dysregulated pH Homeostasis 9781493916825

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Автор: Jen-Tsan Ashley Chi
Название: Molecular Genetics of Dysregulated pH Homeostasis
ISBN: 9781493916825
Издательство: Springer
Классификация:

Медицинское оборудования и методики его эксплуатации

Медицинские исследования

Медицинская генетика

Клеточная биология (цитология)

ISBN-10: 1493916823
Обложка/Формат: Hardcover
Страницы: 160
Вес: 0.42 кг.
Дата издания: 21.10.2014
Язык: English
Издание: 2014 ed.
Иллюстрации: 1 tables, black and white; 12 illustrations, color; 4 illustrations, black and white; viii, 160 p. 16 illus., 12 illus. in color.
Размер: 234 x 156 x 11
Читательская аудитория: Professional & vocational
Основная тема: Human Genetics
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.
Дополнительное описание: Molecular Genetics of Acid Sensing and Response.- Part I: Sensing Acidity.- The molecular mechanism of cellular sensing of acidity.- The Molecular Basis of Sour Sensing in Mammals.- Function and Signaling of the pH-sensing G protein-coupled receptors in p

Molecular Genetics of Dysregulated pH Homeostasis, Jen-Tsan Ashley Chi