Описание: Neoplastic and non-neoplastic diseases of the major and minor salivary glands of the upper aerodigestive tract are, on the whole, relatively uncommon; however, they ignite interest in clinicians from many backgrounds. This book presents a re-evaluation of our understanding of salivary gland disease. There is now an accumulated body of clinical data to add to the longer-standing pathological evidence. This book attempts to integrate the newer clinical findings with the historicaland some editorial comment added as a summary. The authors are all international authorities in their respective fields. It should be read by general and maxillofacial surgeons, oncologists and otolaryngologists, as well as plastic and paediatric surgeons, clinical immunologists and radiologists.
Описание: This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
Автор: Heide Schatten Название: Cell and Molecular Biology of Breast Cancer ISBN: 1627036334 ISBN-13(EAN): 9781627036337 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book.
Описание: This is the first book that discusses subjects of diagnosis, therapy, therapy assessment, and prognosis of breast cancer in one single volume. Cancer killed 6.7
million people around the world in 2002 and this figure is expected to rise to 10.1 million in 2020. Approximately, 189,510 new cases of breast cancer were reported in 2007 in the United
States, and 40,910 died in the same year.
Focusing on Breast Carcinoma, this first volume in the series "Methods of Cancer Diagnosis, Therapy and Prognosis" brings
together 56 leading scientists from around the world to deliver a comprehensive treatise on all aspects of breast cancer, including diagnosis, treatments and prognosis. Scientists and
clinicians have contributed state of the art chapters on their respective areas of expertise providing the reader a whole field view of breast cancer management. This fully illustrated
volume: presents a constructive evaluation of commonly used methods for elucidating primary and secondary cancer initiation, progression, relapse, and metastasis; highlights methods
of breast cancer diagnosis and treatment assessment including various imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging,
immunohistochemistry and histochemistry; discusses detailed therapeutic protocols, including both their benefits and side-effects; discusses examples of breast cancer treatments
including chemotherapy, radiation, chemoradiation, surgery, hormonal - and immunotherapy; details the molecular processes that lead to the development and proliferation of cancer
cells; and, includes recent major advances in cancer diagnosis and therapy assessment.
Professor Hayat has summarized the problems associated with the complexities of
research publications and has been successful in editing a must-read volume for oncologists, cancer researchers
medical teachers and students of cancer biology.
Автор: Maria del Mar Vivanco Название: Mammary Stem Cells ISBN: 1493925180 ISBN-13(EAN): 9781493925186 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.
Автор: Bartsch Название: The Pineal Gland and Cancer ISBN: 3540640517 ISBN-13(EAN): 9783540640516 Издательство: Springer Рейтинг: Цена: 19426.00 р. Наличие на складе: Поставка под заказ.
Описание: The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients.
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