Membrane Transporters as Drug Targets, Gordon L. Amidon; Wolfgang Sad?e

Автор: Susan Napier; Matilda Bingham
Название: Transporters as Targets for Drugs
ISBN: 3642099696 ISBN-13(EAN): 9783642099694
Издательство: Springer
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Цена: 34799.00 р.
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Описание: In each volume of Transporters as Targets for Drugs an overview chapter introduces the newcomer to the topic covered. The series covers hot topics of frontier research summarized by reputed scientists in the field.

Автор: Markus Geisler
Название: Plant ABC Transporters
ISBN: 3319065106 ISBN-13(EAN): 9783319065106
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates.

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319098004 ISBN-13(EAN): 9783319098005
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.