Описание: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg`s well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited.
Автор: DittmarDittmar Название: Stem Cell Biology in Health and Disease 2010 ISBN: 9048130395 ISBN-13(EAN): 9789048130399 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume examines the dual role of stem cells in health and disease. It details strategies on the use of embryonic stem cells and embryonic-like stem cells in regenerative medical purposes as well as strategies on the elimination of cancer stem cells.
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Автор: Gael Cristofari Название: Human Retrotransposons in Health and Disease ISBN: 3319483439 ISBN-13(EAN): 9783319483436 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Retrotransposons and the Mammalian Germline.- L1 regulation in Mouse and Human Germ Cells.- Retrotransposon Contribution to Genomic Plasticity.- The Mobilization of Processed Transcripts in Germline and Somatic Tissues.- Neuronal Genome Plasticity: Retrotransposons, Environment and Disease.- Activity of Retrotransposons in Stem Cells and Differentiated Cells.- Environment, Cellular Signaling and L1 activity.- Retrotransposon-derived Regulatory Regions and Transcripts in Stemness.- Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation.- Alu-Alu Recombinations in Genetic Diseases.- Retrotransposon-driven Transcription and Cancer.- LINE-1 retrotransposons as Neoplastic Biomarkers.- Contribution of Retrotransposable Elements to Aging.
Автор: Willis K. Samson; Ellis Levin Название: Natriuretic Peptides in Health and Disease ISBN: 1461284414 ISBN-13(EAN): 9781461284413 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive, state-of-the-art review of the biochemistry, molecular and cellular biology, pharmacology, physiology, and pathology of natriuretic peptides.
Автор: Adayabalam Balajee Название: DNA Repair and Human Disease ISBN: 1489998993 ISBN-13(EAN): 9781489998996 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
Автор: Daisuke Ekuni; Maurizio Battino; Takaaki Tomofuji; Название: Studies on Periodontal Disease ISBN: 1461495563 ISBN-13(EAN): 9781461495567 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part 4 discusses future strategies, including the effects of antioxidants and nutrition on periodontal disease.This thorough examination of the relationship between oxidative stress and periodontal disease is essential reading for researchers in oxidative stress and periodontal clinicians, alike.
Автор: Keshav K. Singh Название: Mitochondrial DNA Mutations in Aging, Disease and Cancer ISBN: 3662125110 ISBN-13(EAN): 9783662125113 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson`s, Alzheimer`s, and Huntington`s diseases.
Автор: Steven G. Younkin; Rudolph E. Tanzi Название: Presenilins and Alzheimer`s Disease ISBN: 3642721052 ISBN-13(EAN): 9783642721052 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The role of the familial Alzheimer`s Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.
Автор: Christian Behl; Christine Ziegler Название: Cell Aging: Molecular Mechanisms and Implications for Disease ISBN: 3642451780 ISBN-13(EAN): 9783642451782 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors.
Автор: Edelstein, Charles L. Название: Biomarkers of Kidney Disease ISBN: 0128030143 ISBN-13(EAN): 9780128030141 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book.
This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine.
Описание: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family.
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