Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, Deric L. Wheeler; Yosef Yarden

Автор: Daniele Focosi
Название: Resistance to Tyrosine Kinase Inhibitors
ISBN: 3319460900 ISBN-13(EAN): 9783319460901
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

Автор: Frans Tax; Birgit Kemmerling
Название: Receptor-like Kinases in Plants
ISBN: 3642447988 ISBN-13(EAN): 9783642447983
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Revealed by sequencing projects, receptor kinases are the largest group of primary signal transducers in plants. Their abundance hints at an immense network that we have just begun to reveal. This volume focuses on their role, signaling paths, and regulation.

Автор: Bence
Название: Protein Tyrosine Phosphatase Control of Metabolism
ISBN: 1461478545 ISBN-13(EAN): 9781461478546
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This volume highlights many aspects of PTP function in the context of metabolism. It covers the identification of new phosphatases that are involved in metabolic control and includes a review of tissue-specific effects of protein tyrosine phosphatase 1B.

Автор: Pulido
Название: Protein Tyrosine Phosphatases
ISBN: 1493937448 ISBN-13(EAN): 9781493937448
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book provides coverage, methodology, and laboratory protocols on the more essential aspects of protein tyrosine phosphatase (PTP) function and regulation, including the use of standardized in vitro functional assays, suitable cell systems, and animal and microorganism models. Chapters covering state-of-the-art technical approaches suitable to decipher the physiologic roles of PTPs, and their involvement in tissue-specific functions, are also included, which will be of utility for both newcomers and experienced researchers in the field of tyrosine- and phosphoinositide- phosphorylation/dephosphorylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Автор: Jenny, Andreas
Название: Protein Kinases in Development and Disease,123
ISBN: 0128015136 ISBN-13(EAN): 9780128015131
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Описание:

Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease.

Автор: Valdur A. Saks; Ren?e Ventura-Clapier
Название: Cellular Bioenergetics: Role of Coupled Creatine Kinases
ISBN: 1461361192 ISBN-13(EAN): 9781461361190
Издательство: Springer
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Цена: 18284.00 р.
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Описание: The editors of this volume invited all authors who are most active at present in experimental research on creatine kinases to summarize their work and make the information easily available to a wider scientific audience, especially to young investigators who are entering this field.

Автор: Inouye
Название: Histidine Kinases in Signal Transduction
ISBN: 0123724848 ISBN-13(EAN): 9780123724847
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Описание: Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. This book provides a review on the structure and function of histidine kinases. It also offers information on the physiological roles of histidine kinases in bacteria and eukaryotes.

Автор: Marc Daeron; Eric Vivier
Название: Immunoreceptor Tyrosine-based Inhibition Motifs
ISBN: 3642636349 ISBN-13(EAN): 9783642636349
Издательство: Springer
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Цена: 15672.00 р.
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Описание: Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation.

Автор: Anthony Koleske
Название: Abl Family Kinases in Development and Disease
ISBN: 1489995536 ISBN-13(EAN): 9781489995537
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.

Автор: Neel
Название: Protein Tyrosine Phosphatases in Cancer
ISBN: 1493936476 ISBN-13(EAN): 9781493936472
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.