Recent Advances in Glucocorticoid Receptor Action, A. Cato; H. Schaecke; K. Asadullah
Автор: Gurevich Название: G Protein-Coupled Receptor Kinases ISBN: 1493937960 ISBN-13(EAN): 9781493937967 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory.
Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.
Описание: "Drug-Receptor Thermodynamics" covers the general principles of thermodynamics and its use and utility in pharmacology; provides a review of actual applications arranged according to receptor categories; and discusses the potential for thermodynamics to some day predict drug action.
Автор: Martial Ruat Название: The Smoothened Receptor in Cancer and Regenerative Medicine ISBN: 3319197541 ISBN-13(EAN): 9783319197548 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.
Автор: Majed M. Hamawy Название: IgE Receptor (Fc?RI) Function in Mast Cells and Basophils ISBN: 3662220245 ISBN-13(EAN): 9783662220245 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.
Автор: Tomohiro Kurosaki; J?rgen Wienands Название: B Cell Receptor Signaling ISBN: 3319261312 ISBN-13(EAN): 9783319261317 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases.
Автор: Jordan V Craig Название: Estrogen Action, Selective Estrogen Receptor Modulators and ISBN: 1848169574 ISBN-13(EAN): 9781848169579 Издательство: World Scientific Publishing Рейтинг: Цена: 26928.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Presents the evolution of the authors` ideas about estrogen action and its modulation by a fresh group of drugs called SERMs (Selective Estrogen Receptor Modulators). This title presents a journey over years of discovery and success in advancing women`s health, with the prospect of improved medicinal chemistry for the future.
Автор: George Poste; Stanley T. Crooke Название: Dopamine Receptor Agonists ISBN: 1475703120 ISBN-13(EAN): 9781475703122 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner- vous system.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 3319051601 ISBN-13(EAN): 9783319051604 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 364254214X ISBN-13(EAN): 9783642542145 Издательство: Springer Рейтинг: Цена: 53106.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field will describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Описание: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family.
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