Автор: De Ley Название: Cytokine Protocols ISBN: 1617794384 ISBN-13(EAN): 9781617794384 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: “Recent studies have discovered new known and characterized cytokines, allowing for advancement in miniaturization of micro-analytical methods as well as the extensive development of bio-informatics and nanotechnology. These advancements have allowed researchers to reduces sample sizes making for more accurate determinations then previously possible. In Cytokine Protocols: Second Edition, expert researchers in the field detail many of the methods which are now commonly used to study cytokines. These methods and techniques for studying cytokines include historical importance and the importance of researchers using bioassay, quantification, and characterization of cytokine related RNAs, posttranscriptional modifications of RNA, either naturally or artificially, and observations at the protein level. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and practical, Cytokine Protocols: Second Edition seeks to aid scientists in furthering the crucially important advancement of cytokine research.”
Описание: This book explores the major cytokines, such as IL-1 and IFN-?, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Автор: Balkwill Название: Cytokine Mol. Biology ISBN: 0199638578 ISBN-13(EAN): 9780199638574 Издательство: Oxford Academ Рейтинг: Цена: 13464.00 р. Наличие на складе: Поставка под заказ.
Описание: This work focuses on molecular biology techniques for the study of cytokines, cytokine receptors, and cytokine driven processes. Updated topics from the previous edition include: the cloning and expressing cytokine genes; the detection of cytokine MRNA; and receptor binding studies.
Автор: Katherine A. Fitzgerald Название: The Cytokine Factsbook and Webfacts, ISBN: 0121551423 ISBN-13(EAN): 9780121551421 Издательство: Elsevier Science Рейтинг: Цена: 18275.00 р. Наличие на складе: Поставка под заказ.
Описание: This is a reference manual for all current well-characterised interleukins, cytokines and their receptors. Introductory chapters provide background information on the cytokine network and cytokine receptor superfamilies. This is followed by over 100 comprehensive individual entries covering each characterised cytokine/chemokine/growth factor. Information is also provided on cytokine standards and protein sequence retrieval database servers. The manual also includes free online access to Cytokine Webfacts, which provides online access to a comprehensive compendium of facts about cytokines and their receptors. This compendium includes a variety of data representations, such as text information, signal pathway diagrams and 3D images.
Автор: Balkwill Название: Cytokine Molecular Biology ISBN: 0199638594 ISBN-13(EAN): 9780199638598 Издательство: Oxford Academ Рейтинг: Цена: 13464.00 р. Наличие на складе: Поставка под заказ.
Описание: This work examines techniques for studying cytokines, cytokine receptors, and cytokine driven processes. Assays for human B-cell responses, leucocyte migration, haematopoietic growth factors, macrophage activation by cytokine and quantitative biological assays for cytokines are covered.
Автор: G.A.W. Rook; S. Lightman Название: Steroid Hormones and the T-Cell Cytokine Profile ISBN: 1447112385 ISBN-13(EAN): 9781447112389 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ThI-enhancing effects of another adrenal steroid, dehydroepiandro- sterone sulfate (DHEAS). Second, the activity of cortisol is directly modulated by enzymes in the target organs and lymphoid tissues that convert it into inactive cortisone. This new information leads to the possibility that immunoregulatory steroids could be used by physicians in novel ways. We can envisage steroid combinations that exploit the anti-inflammatory effects of corti- sol, while the Thi-suppressing and Th2-promoting properties of these hormones are opposed by derivatives of DHEAS. Such therapies are already proving effective in animal models of infection, and could revol- utionize treatment of Th2-mediated diseases such as asthma, where the anti-inflammatory effects of cortisol are desirable but the effects on T lymphocyte differentiation are not.
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