The Complex connection between cannabis and schizophrenia, Michael T. Compton and Marc Manseau
Автор: Neal R. Swerdlow Название: Behavioral Neurobiology of Schizophrenia and Its Treatment ISBN: 364226462X ISBN-13(EAN): 9783642264627 Издательство: Springer Рейтинг: Цена: 41787.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by leading authorities in the field, this book describes the state-of-the-art of treatment of schizophrenia and reflects its development. It provides new tools to access and target real-life function and functional outcome in the schizophrenia.
Описание: This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
Автор: Sylvain Celanire; Sonia Poli Название: Small Molecule Therapeutics for Schizophrenia ISBN: 3319115014 ISBN-13(EAN): 9783319115016 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Antipsychotics and the Dopamine-Serotonin Connection.- GLYT1 Inhibitors: From Hits to Clinical Candidates.- Metabotropic Glutamate Receptor 2 Activators.- Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders.- Muscarinic Acetylcholine Receptor Activators.- Nicotinic Acetylcholine Receptor Modulators.- The Use of PDE10A and PDE9 Inhibitors for Treating Schizophrenia.
Автор: C.L. Cazzullo; G. Invernizzi; E. Sacchetti; A. Vit Название: Etiopathogenetic Hypotheses of Schizophrenia ISBN: 9401079390 ISBN-13(EAN): 9789401079396 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Going ahead with their plans, the Association for Research on Schizophrenia CARS), the Schizophrenia Research Group of the Institute of Psychiatry of the University of Milan and the Tito and Fanny Legrenzi Foundation organized the International Meeting "Etiopathogenetic Hypotheses of Schizophrenia: The Impact of Epidemiological, Biochemical and Neuromorphological Studies", held in Milan on October 3-4 1986. The Meeting was an excellent occasion for the exchange of information and the sharing of views on the etiological hypotheses of schizophrenia resulting from the latest research in the key areas of epidemiology, biochemistry amd brain imaging. We are very pleased and proud to have had so many of the leading researchers in schizophrenia with us. Their stimulating and friendly presence and their contributions made this Meeting a great success. We hope that this book, a collection of the various participants' contributions at the Meeting, will have an equally favourable reception. The Editors viii List of contributors N. C. Andreasen A. Breier W. Christie The University of Iowa Clinical Neuroscience Klinikum Charlottemburg Hospitals and Clinics Branch, NIHM Department of Neurology Department of Psychiatry Building 10, Room 4N 214 Spandau Damm 130 9000 Rockville Pike D-1000 Berlin 19 500 Newton Road Iowa City, IA 52242 Bethesda, MD 20892 West Germany USA USA C. Cignarale M. Battaglia A. Calzeroni Chair of Clinical Psychiatry S. Maria di Collemaggio Institute of Psychiatry Institute of Psychiatry Milan University Milan University Hospital Policlinico -Pad.
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