Toxicity and Biodegradation Testing, Ederio Dino Bidoia; Renato Nallin Montagnolli

Автор: Balls, Michael; Combes, Robert D.; Bhogal, Nirmala (Eds.)
Название: New Technologies for Toxicity Testing
ISBN: 1461430542 ISBN-13(EAN): 9781461430544
Издательство: Springer
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Описание: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.

Автор: Jim C. Spain
Название: Biodegradation of Nitroaromatic Compounds
ISBN: 1475794495 ISBN-13(EAN): 9781475794496
Издательство: Springer
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Описание: Based in part on the symposium on Biodegradation of Nitroaromatic Compounds held in Las Vegas, Nevada, May 22-23, 1994

Автор: Jim C. Spain
Название: Biodegradation of Nitroaromatic Compounds
ISBN: 0306450143 ISBN-13(EAN): 9780306450143
Издательство: Springer
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Описание: Based in part on the symposium on Biodegradation of Nitroaromatic Compounds held in Las Vegas, Nevada, May 22-23, 1994

Автор: Eskes
Название: Validation of Alternative Methods for Toxicity Testing
ISBN: 3319338242 ISBN-13(EAN): 9783319338248
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.