MicroRNA and Cancer, Wei Wu

Автор: Xueji Zhang; Haifeng Dong; Yaping Tian
Название: MicroRNA Detection and Pathological Functions
ISBN: 3662472929 ISBN-13(EAN): 9783662472927
Издательство: Springer
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Цена: 7685.00 р.
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Описание: This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.

Автор: Suresh Alahari
Название: MicroRNA in Cancer
ISBN: 9401784930 ISBN-13(EAN): 9789401784931
Издательство: Springer
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Цена: 15672.00 р.
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Описание: This book explores the rapidly emerging field of microRNA biology, highlighting the importance of microRNAs in cancer. This first reference of its kind will benefit working scientists in cancer biology, as well as advanced undergraduate and graduate students.

Автор: Singh Shree Ram
Название: MicroRNA in Development and in the Progression of Cancer
ISBN: 1489980644 ISBN-13(EAN): 9781489980649
Издательство: Springer
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Цена: 23757.00 р.
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Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

Автор: Fazlul H. Sarkar
Название: MicroRNA Targeted Cancer Therapy
ISBN: 3319051334 ISBN-13(EAN): 9783319051338
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.

Автор: Ulf Schmitz; Olaf Wolkenhauer; Julio Vera
Название: MicroRNA Cancer Regulation
ISBN: 9402400796 ISBN-13(EAN): 9789402400793
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book discusses the role of microRNAs in the formation and progression of solid tumors. The main focus is on computational methods and applications, together with experimental techniques used to approach all aspects of microRNA regulation in cancer.

Автор: Fazlul H. Sarkar
Название: MicroRNA Targeted Cancer Therapy
ISBN: 3319376063 ISBN-13(EAN): 9783319376066
Издательство: Springer
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Цена: 19589.00 р.
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Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.

Автор: Shree Ram Singh; Pranela Rameshwar
Название: MicroRNA in Development and in the Progression of Cancer
ISBN: 1493944916 ISBN-13(EAN): 9781493944910
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy.

Автор: Wei Wu
Название: MicroRNA and Cancer
ISBN: 1493957740 ISBN-13(EAN): 9781493957743
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Authoritative and cutting-edge, this book provides the basic principles of experimental and computational methods for microRNA study in cancer research. It provides a firm grounding for those who wish to further develop their own applications.

Автор: Jingshan Huang; Glen M. Borchert; Dejing Dou; Jun
Название: Bioinformatics in MicroRNA Research
ISBN: 1493970445 ISBN-13(EAN): 9781493970445
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

1. MicroRNAs, Long Non-Coding RNAs, and Their Functions in Human Disease

Автор: William C.S. Cho
Название: MicroRNAs in Cancer Translational Research
ISBN: 9400789971 ISBN-13(EAN): 9789400789975
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This timely publication includes chapters by world-renowned experts and focuses on our current understanding of miRNAs. It assesses their potential applications in cancer diagnosis, prognosis and therapeutic targets, and identifies areas for further research.