Автор: Zhang Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 1607617684 ISBN-13(EAN): 9781607617686 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.
Автор: Wei Wu Название: MicroRNA and Cancer ISBN: 1493974335 ISBN-13(EAN): 9781493974337 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part I: Review
1. Non- coding RNAs in DNA Damage Response: Opportunities for Cancer Therapeutics
Wani Arjumand, Asia Asiaf, and Shiekh Tanveer Ahmad
2. MicroRNAs in Breast Cancer: Diagnostic and Therapeutic Potential
Asia Asiaf, Shiekh Tanveer Ahmad, Wani Arjumand, and Mohammad Afzal Zargar
3. Involvement of miRNAs and Pseudogenes in Cancer
Lьtfi TUTAR, Aykut ЦZGЬR, and Yusuf TUTAR
4. microRNAs Reprogram Tumor Immune Response
Wenfang Cheng and Wei Wu
5. APOBEC Gene Expression Regulated by microRNAs
Wei Cao and Wei Wu
6. MicroRNAs Changes the Landscape of Cancer Resistance
Jun Zhu and Wei Wu
7. MicroRNA, Noise, and Gene Expression Regulation
Wei Wu
PART II: Protocol Section
8. Deep Sequencing Reveals a microRNA Expression Signature in
Triple-negative Breast Cancer
Yao-Yin Chang, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang
9. Detection of Plasma microRNA Signature in Osteosarcoma Patients
Wendy Allen-Rhoades and Jason T. Yustein
10. Identification of E6/E7-dependent microRNAs in HPV-positive Cancer Cells
Anja Honegger, Daniela Schilling, Holger Sьltmann, Karin Hoppe-Seyler, and Felix Hoppe-Seyler
11. Combination of Anti-miRNAs Oligonucleotides with Low Amounts of Chemotherapeutic Agents for Pancreatic Cancer Therapy
Marta Passadouro and Henrique Faneca
12. Evaluation of microRNA Delivery in vivo
Rikki A. M. Brown, Kirsty L. Richardson, Felicity C. Kalinowski, Michael R. Epis, Jessica L. Horsham, Tasnuva D. Kabir, Marisa H. De Pinho, Dianne J. Beveridge, Lisa M. Stuart, Larissa C. Wintle, and Peter J. Leedman
13. Angiogenesis A
nalysis by in vitro Co-culture Assays in Transwell Chambers in Ovarian Cancer
Ali Flores-Pйrez, Dolores Gallardo Rincуn, Erika Ruiz-Garcнa, Raquel Echavarria, Laurence A. Marchat, Elizbeth Бlvarez-Sбnchez, and Cйsar Lуpez-Camarillo
14. Application of Individual qPCR Performance Parameters for Quality Control of Circulating microRNA Data
Anna Brunet-Vega, Marнa Elisa Quнlez, Marнa Josй Ramнrez-Lбzaro, andSergio Lario
15. Construction of Multi-potent microRNA Sponge and its Functional Evaluation
Suhwan Chang
16. microRNA Sequencing Data Analysis Toolkits
Wei Wu
Автор: Wei Wu Название: MicroRNA and Cancer ISBN: 1493957740 ISBN-13(EAN): 9781493957743 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Authoritative and cutting-edge, this book provides the basic principles of experimental and computational methods for microRNA study in cancer research. It provides a firm grounding for those who wish to further develop their own applications.
Автор: Rani Название: MicroRNA Profiling ISBN: 1493965220 ISBN-13(EAN): 9781493965229 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume includes comprehensive descriptions of miRNA biogenesis and their role in the development and progression of various human diseases. The first few chapters of MicroRNA Profiling: Methods and Protocols discuss the effects of over-expressing and repressing of a target miRNA and their effects on cell viability and proliferation. The next few chapters explore the protocols for total RNA isolation from cells and cell-derived product including formalin fixed paraffin embedded tissue and plant tissue. The last few chapters discuss isolation and characterization of exosomes from medium conditioned by cell lines, serum, and plasma specimens. This book also includes discussions of several software tools, such as miRandola, PicTar, DIANA, and miRWalk. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, MicroRNA Profiling: Methods and Protocols is a valuable resource for anyone interested in the field of Micro RNAs.
Автор: Tamas Dalmay Название: MicroRNA Detection and Target Identification ISBN: 1493968645 ISBN-13(EAN): 9781493968640 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection of miRNA detection and target identification protocols details new developments in traditional detection such as northern blot, quantitative real-time PCR and in situ hybridization, and guides through novel approaches such as nanotechnology, microfluidics, based detection methods, miRNAs as biomarkers and others.
Автор: Jingshan Huang; Glen M. Borchert; Dejing Dou; Jun Название: Bioinformatics in MicroRNA Research ISBN: 1493970445 ISBN-13(EAN): 9781493970445 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. MicroRNAs, Long Non-Coding RNAs, and Their Functions in Human Disease
Min Xue, Ying Zhuo, and Bin Shan
2. MicroRNA Expression: Protein Participants in MicroRNA Regulation
4. MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
Weili Huang
5. Relational Databases and Biomedical Big Data
N.H. Nisansa D. de Silva
6. Semantic Technologies and Bio-Ontologies
Fernando Gutierrez
7. Genome-Wide Analysis of MicroRNA-Regulated Transcripts
David Chevalier and Glen M. Borchert
8. Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
Justin T. Roberts and Glen M. Borchert
9. Exploring MicroRNA:: Target Regulatory Interactions by Computing Technologies
Yue Hu, Wenjun Lan, and Daniel Miller
10. The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy
Rasiah Loganantharaj and Thomas A. Randall
11. Genomic Regulation of MicroRNA Expression in Disease Development
Feng Liu
12. Next Generation Sequencing for MicroRNA Expression Profile
Yue Hu, Wenjun Lan, and Daniel Miller
13. Handling High-Dimension (High-Feature) MicroRNA Data
Yue Hu, Wenjun Lan, and Daniel Miller
14. Effective Removal of Noisy Data Via Batch Effect Processing
Ryan G. Benton
15. Logical Reasoning (Inferencing) on MicroRNA Data
Jingsong Wang
16. Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions
Sumi Singh, Ryan G. Benton, Anurag Singh, and Anshuman Singh
17. Involvement of MicroRNAs in Diabetes and Its Complications
Bin Wu and Daniel Miller
18. MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role
Lihua Zhang, Daniel Miller, Qiuping Yang, and Bin Wu
19. Expression of MicroRNAs in Thyroid Carcinoma
Gaohong Zhu, Lijun Xie, and Daniel Miller
Автор: Fazlul H. Sarkar Название: MicroRNA Targeted Cancer Therapy ISBN: 3319051334 ISBN-13(EAN): 9783319051338 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.
Автор: Ulf Schmitz; Olaf Wolkenhauer; Julio Vera Название: MicroRNA Cancer Regulation ISBN: 9402400796 ISBN-13(EAN): 9789402400793 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the role of microRNAs in the formation and progression of solid tumors. The main focus is on computational methods and applications, together with experimental techniques used to approach all aspects of microRNA regulation in cancer.
Автор: Shree Ram Singh; Pranela Rameshwar Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1493944916 ISBN-13(EAN): 9781493944910 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy.
Автор: Xueji Zhang; Haifeng Dong; Yaping Tian Название: MicroRNA Detection and Pathological Functions ISBN: 3662472929 ISBN-13(EAN): 9783662472927 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.
Автор: Zhiguo Wang; Baofeng Yang Название: MicroRNA Expression Detection Methods ISBN: 3642425186 ISBN-13(EAN): 9783642425189 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides comprehensive descriptions of the innovative strategies and methodologies for detecting miRNA expression as well as their application in miRNA research and their potential as tools for clinical diagnosis and prognosis.
Автор: Singh Shree Ram Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1489980644 ISBN-13(EAN): 9781489980649 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
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