Early Phase Cancer Immunotherapy, Sandip Patel; Razelle Kurzrock

Автор: Yotnda
Название: Immunotherapy of Cancer
ISBN: 1607617854 ISBN-13(EAN): 9781607617853
Издательство: Springer
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Цена: 23058.00 р.
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Описание: This book describes detailed procedures for trainees and experts in the area of basic, clinical science who wish to undertake their own cutting-edge immunotherapy studies. It includes coverage of pre-clinical models for cancer immunotherapy.

Автор: Dranoff
Название: Cancer Immunology and Immunotherapy
ISBN: 3642141358 ISBN-13(EAN): 9783642141355
Издательство: Springer
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Цена: 28734.00 р.
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Описание: The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Автор: Britten
Название: Cancer Immunotherapy Meets Oncology
ISBN: 3319051032 ISBN-13(EAN): 9783319051031
Издательство: Springer
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Цена: 20962.00 р.
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Автор: James H. Finke; Ronald M. Bukowski
Название: Cancer Immunotherapy at the Crossroads
ISBN: 1468498444 ISBN-13(EAN): 9781468498448
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction.

Автор: Glenn Dranoff
Название: Cancer Immunology and Immunotherapy
ISBN: 3642267882 ISBN-13(EAN): 9783642267888
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Cancer Immunotherapy discusses tumor-immune interactions in several human cancers. The text proposes an integrated scheme of the impact of local immune reactions on clinical outcome, and illustrates various aspects of this complexity.

Название: Immunotherapy of cancer
ISBN: 4431550305 ISBN-13(EAN): 9784431550303
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Автор: George C. Prendergast
Название: Cancer Immunotherapy,
ISBN: 0123942969 ISBN-13(EAN): 9780123942968
Издательство: Elsevier Science
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Цена: 16169.00 р.
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Описание: There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles.

Автор: Paul Koldovsky; Ursula Koldovsky; Lutwin Beck; Kar
Название: Lymphocytes in Immunotherapy of Cancer
ISBN: 3540504575 ISBN-13(EAN): 9783540504573
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Vaccination has been investigated clinically for its po- tential to prevent cancer [1], and clinical research into the cure of cancer has included active immunization [2], nonspecific stimulation of defense mechanisms [3], and transfer of passive immunity by cells [4] or by antibodies [5].

Автор: Rong-Fu Wang
Название: Innate Immune Regulation and Cancer Immunotherapy
ISBN: 1489985905 ISBN-13(EAN): 9781489985903
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. This book discusses recent progress in innate immunity and Treg cells, and the regulation of innate immunity through Toll-like receptor (TLR) signalling.

Автор: Mary L. Disis
Название: Immunotherapy of Cancer
ISBN: 1617376450 ISBN-13(EAN): 9781617376450
Издательство: Springer
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Цена: 36570.00 р.
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Описание: Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments.

Автор: Benjamin Bonavida; Salem Chouaib
Название: Resistance of Cancer Cells to CTL-Mediated Immunotherapy
ISBN: 3319178067 ISBN-13(EAN): 9783319178066
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.