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Vaccines: Are they Worth a Shot?, Andrea Grignolio; Joan Rundo


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Цена: 4191.00р.
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Автор: Andrea Grignolio; Joan Rundo
Название:  Vaccines: Are they Worth a Shot?
ISBN: 9783319681054
Издательство: Springer
Классификация:


ISBN-10: 3319681052
Обложка/Формат: Paperback
Страницы: 200
Вес: 0.23 кг.
Дата издания: 26.02.2018
Язык: English
Издание: 1st ed. 2018
Иллюстрации: 3 illustrations, color; 2 illustrations, black and white; xii, 181 p. 5 illus., 3 illus. in color.
Размер: 237 x 173 x 13
Читательская аудитория: General (us: trade)
Основная тема: Popular Science
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: 1. The parents of unvaccinated children

1.1. The 80s, the beginning of the crisis (or resistance)

1.2. Education about risk

1.3. Social changes: The doctor-patient relationship in jeopardy

1.4. Unexpected impact of late fecundity

2. A brief history of the anti-vaccination movements

2.1. The anti-vaccination movements between 1700 and 1800: Roots of obligation and objection

2.2. The anti-vaccination movements in 1900: Media and politics

3. Web alarms: autism, mercury and immune overload

3.1. Conspiracy on the Internet: separating fact from fiction

3.2. Economic criticism: Big Pharma and the allure of patents

3.3. Logic errors: the precautionary principle and the equal balance mistake

3.4. False or manipulated data: Autism

3.5. Prejudices and ideologies: Purported overload and weakening of the immune system

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4. The antivax experts five ways to recognize them

4.1. Alternative philosophies: homeopathy, anthroposophy and Waldarf -Steiner schools

4.2. The alternative therapies Five clues that reveal a charlatan

5. Past, present, and future of vaccines

5.1. Evolutionary history of naturally acquired immunity

5.2. Artificially acquired immunity: success and safety of vaccines

5.3. Therapeutic vaccines of the future: cancer and neurodegenerative diseases

6. Conclusions

6.1. A new alliance between scientists and citizens for a knowledge society

6.2. Some tools for good communication strategies to combat anti-vaccination resistance

Дополнительное описание: The parents of unvaccinated children.- A brief history of the anti-vaccination movements.- Web alarms: autism, mercury and immune overload.- The antivax “experts": five ways to recognize them.- Past, present, and future of vaccines.- Conclusions.



Lyophilized Biologics and Vaccines

Автор: Dushyant Varshney; Manmohan Singh
Название: Lyophilized Biologics and Vaccines
ISBN: 1493955683 ISBN-13(EAN): 9781493955688
Издательство: Springer
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Цена: 16070.00 р.
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Описание: This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products. Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: * Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulations * Details the latest developments in instrumental analysis and controlled ice nucleation technology * Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeutics * Details an exhaustive update on quality-by-design and process analytical technology approaches, illustrated superbly by case studies and FDA perspective * Provides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studies * Provides a step-by-step guide through critical considerations during process scale-up, technology transfer, packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launch Chapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.

Cancer Vaccines

Автор: Michael J.P. Lawman; Patricia D. Lawman
Название: Cancer Vaccines
ISBN: 1493951955 ISBN-13(EAN): 9781493951956
Издательство: Springer
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Цена: 21661.00 р.
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Описание:

Part I: Manipulation and Modification of Immune Cells: Dendritic Cells

1. Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules

Daphnй Benteyn, An M.T. Van Nuffel, Sofie Wilgenhof, and Aude Bonehill

2. Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine

Hyun-Ju Lee, Nu-Ri Choi, Manh-Cuong Vo, My-Dung Hoang, Youn-Kyung Lee, and Je-Jung Lee

3. Pulsing Dendritic Cells with Whole Tumor Cell Lysates

Laura Alaniz, Manglio M. Rizzo, and Guillermo Mazzolini

4. Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy

Chiranjib Pal

5. Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens

Manglio M. Rizzo, Laura Alaniz, and Guillermo Mazzolini

6. Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma

Sumit K. Hira, Deepak Verma, and Partha P. Manna

7. Dendritic Cells Primed with Protein-Protein Fusion Adjuvant

Liying Wang and Yongli Yu

8. Antigen-Specific mRNA Transfection of Autologous Dendritic Cells

Fabian Benencia

9. Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material

Francesca Milano and K.K. Krishnadath

10. Dendritic Cells Transfected with Adenoviral Vectors as Vaccines

Joseph Senesac, Dmitry Gabrilovich, Samuel Pirruccello, and James E. Talmadge

11. Genetic Modification of Dendritic Cells with RNAi

Xiao-Tong Song

12. Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy

Gamal Ramadan

13. Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation

Naoshi Kawamura, Masaru Udagawa, Tomonobu Fujita, Toshiharu Sakurai, Tomonori Yaguchi, and Yutaka Kawakami

14. Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines

Roeland Lameris, Famke L. Schneiders, Tanja D. de Gruijl, and Hans J. van der Vliet

Part II: Manipulation and Modification of Immune Cells: T Lymphocytes and NK Cells

15. Modification of T Lymphocytes to Express Tumor Antigens

Aaron E. Foster and Xiao-Tong Song

16. Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor

Liza B. John, Tess M. Chee, David E. Gilham, and Phillip K. Darcy

17. Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors

Serena K. Perna, Barbara Savoldo, and Gianpietro Dotti

18. Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients

Chiara Camisaschi, Marcella Tazzari, Licia Rivoltini, and Chiara Castelli

19. Cytokine Activation of Natural Killer Cells

Syh-Jae Lin, Pei-Tzu Lee, and Ming-Ling Kuo

Part III: Manipulation and Modification of Tumor Cells

20. Loading of Acute Myeloid Leukemia Cells with Poly(I: C) by Electroporation

Eva Lion, Charlotte M. de Winde, Viggo F.I. Van Tendeloo, and Evelien L.J.M. Smits

21. Autologous Tumor Cells Engineered to Express Bacterial Antigens

Vijayakumar K. Ramiya, Maya M. Jerald, Patricia D. Lawman, and Michael J.P. Lawman

22. Tumor Cell Transformation Using Antisense Oligonucleotide

Mohamed R. Akl and Nehad M. Ayoub

23. The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy

Haval Shirwan, Esma S. Yolcu, Rajesh K. Sharma, Hong Zaho, and Orlando Grimany-Nuno

Part IV: Manipulation of Immune/Tumor Interactions

24. Cloning Variable

Vaccines and Autoimmunity

Автор: Yehuda Shoenfeld,Nancy Agmon–Levin
Название: Vaccines and Autoimmunity
ISBN: 1118663438 ISBN-13(EAN): 9781118663431
Издательство: Wiley
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Цена: 22485.00 р.
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Описание: In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants specifically aluminum in different vaccines and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.

Genetically Engineered Vaccines

Автор: Joseph E. Ciardi; Jerry R. McGhee; Jerry M. Keith
Название: Genetically Engineered Vaccines
ISBN: 1461365074 ISBN-13(EAN): 9781461365075
Издательство: Springer
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Цена: 6986.00 р.
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Malaria Vaccines

Автор: Ashley Vaughan
Название: Malaria Vaccines
ISBN: 1493949020 ISBN-13(EAN): 9781493949021
Издательство: Springer
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Цена: 15672.00 р.
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Описание: The chapters within this book talk about interventions concerning all aspects of life cycle progression--measuring antibody responses to blood stage parasite survival, the T Cell responses engendered by attenuated sporozoite vaccinations, and the unique effect on transmission of antibodies that target the mosquito stage of the life cycle.

DNA Vaccines

Автор: Hildegund Ertl
Название: DNA Vaccines
ISBN: 1461349257 ISBN-13(EAN): 9781461349259
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Antigens encoded by DNA vaccines can induce all arms of the adaptive immune response, but to date they have proven most effective at inducing antigen-specific CD8+ T cells. The rational modification of DNA vaccines requires that we have a basic understanding of the mechanisms which underpin successful DNA immuniza- tion.

Vaccines

Автор: Anthony C. Allison; Gregory Gregoriadis; George Po
Название: Vaccines
ISBN: 1461367174 ISBN-13(EAN): 9781461367178
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1990

New Generation Vaccines

Автор: Gregory Gregoriadis; Brenda McCormack; Anthony C.
Название: New Generation Vaccines
ISBN: 1461362814 ISBN-13(EAN): 9781461362814
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1992.

New Trends and Developments in Vaccines

Автор: A. Voller; C.M. Abraham
Название: New Trends and Developments in Vaccines
ISBN: 9401166323 ISBN-13(EAN): 9789401166324
Издательство: Springer
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Цена: 6986.00 р.
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Описание: It was not too long ago that many physicians and biomedical scientists felt that the era of `vaccines` for protecting mankind against infectious disease was coming to an end.

Vaccines

Автор: Peter Perlman; Hans Wigzell
Название: Vaccines
ISBN: 3642641962 ISBN-13(EAN): 9783642641961
Издательство: Springer
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Цена: 18167.00 р.
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Описание: With contributions by numerous experts

Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines

Автор: Jean-Pierre Kraehenbuhl; Marian R. Neutra
Название: Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines
ISBN: 3642641946 ISBN-13(EAN): 9783642641947
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Mucosal immunity encompasses a broad field of research that includes areas of epithelial cell and molecular biology, molecular and cellular immunology, microbiology, virology, and vaccinology. It provides an overview of the components of the mucosal immune system, and the basic science relevant to mucosal vaccination.

Vaccines for Pandemic Influenza

Автор: Richard W Compans; Walter A. Orenstein
Название: Vaccines for Pandemic Influenza
ISBN: 3642242405 ISBN-13(EAN): 9783642242403
Издательство: Springer
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Цена: 36570.00 р.
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Описание: The outbreak of disease caused by a H1N1 virus has focused global attention on the threat of an influenza pandemic. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans resulting in numerous fatalities. This title deals with this topic.


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