Resistance to Targeted Therapies in Breast Cancer, Jenifer Prosperi

Автор: Burstein, Harold
Название: Targeted therapies in breast cancer
ISBN: 0199735670 ISBN-13(EAN): 9780199735679
Издательство: Oxford Academ
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Цена: 2549.00 р. 3642.00 -30%
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Описание: This book provides clinicians with ultra-concise, evidence-based current information and insight on implementing the latest treatment strategies, for treating breast cancer, including targeted agents, into clinical practice.

Автор: Ricardo H Alvarez; Javier Cort?s; Mary Falzon; Mic
Название: Handbook of HER2-Targeted Agents in Breast Cancer
ISBN: 331928214X ISBN-13(EAN): 9783319282145
Издательство: Springer
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Цена: 8384.00 р.
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Описание: This concise handbook provides oncologists and other healthcare providers with crucial updates in the field, including an updated review of the current understanding of the biology of the HER2 pathway, an overview of HER2-testing, and evidence-based discussions of available and emerging HER2-targeted treatment options.

Автор: Amanda Tivnan
Название: Resistance to Targeted Therapies Against Adult Brain Cancers
ISBN: 331946504X ISBN-13(EAN): 9783319465043
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319098004 ISBN-13(EAN): 9783319098005
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319379968 ISBN-13(EAN): 9783319379968
Издательство: Springer
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Цена: 20896.00 р.
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors.

Автор: Manfred Dietel
Название: Targeted Therapies in Cancer
ISBN: 3642432433 ISBN-13(EAN): 9783642432439
Издательство: Springer
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Цена: 23757.00 р.
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Описание: From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Автор: Francesco Colotta; Alberto Mantovani
Название: Targeted Therapies in Cancer:
ISBN: 1441925376 ISBN-13(EAN): 9781441925374
Издательство: Springer
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Цена: 20896.00 р.
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Описание: This crucial text offers readers an overview of diverse approaches to targeted cancer therapies, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.

Автор: Daniel Gioeli
Название: Targeted Therapies
ISBN: 1617797448 ISBN-13(EAN): 9781617797446
Издательство: Springer
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Цена: 27951.00 р.
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Описание: Targeted Therapies highlights changes in the signaling network in response to inhibition of a signaling event. The text illustrates how a mechanistic understanding of the signaling network in cancer is important to developing targeted cancer therapies.

Автор: Antonio Russo; Rafael Rosell; Christian Rolfo
Название: Targeted Therapies for Solid Tumors
ISBN: 1493920464 ISBN-13(EAN): 9781493920464
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Targeted Therapies for Solid Tumors

Автор: Federico Cappuzzo
Название: Guide to Targeted Therapies: EGFR mutations in NSCLC
ISBN: 3319030582 ISBN-13(EAN): 9783319030586
Издательство: Springer
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Цена: 5589.00 р.
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Описание: This concise, practical handbook discusses EGFR mutations in NSCLC, testing methods and technology, current and emerging therapies, and resources. It offers readers a fast synopsis of key studies and available treatment options.