Описание: Motor dysfunction and cognitive impairment are major symptoms in both Huntington`s Disease (HD) and Parkinson`s Disease (PD). This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Автор: Verstreken, Patrik Название: Parkinson`s Disease ISBN: 0128037830 ISBN-13(EAN): 9780128037836 Издательство: Elsevier Science Рейтинг: Цена: 11193.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. . This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes.Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Автор: DittmarDittmar Название: Stem Cell Biology in Health and Disease 2010 ISBN: 9048130395 ISBN-13(EAN): 9789048130399 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume examines the dual role of stem cells in health and disease. It details strategies on the use of embryonic stem cells and embryonic-like stem cells in regenerative medical purposes as well as strategies on the elimination of cancer stem cells.
Автор: Abraham Fisher; Maurizio Memo; Fabrizio Stocchi; I Название: Advances in Alzheimer`s and Parkinson`s Disease ISBN: 1441944230 ISBN-13(EAN): 9781441944238 Издательство: Springer Рейтинг: Цена: 43184.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains the proceedings of the 2005 ADPD conference and is unique in that it deals not only with issues related individually to Alzheimer`s disease and Parkinson`s disease, but also with the integration of these and other related diseases.
Автор: Patrik Brundin; C. Warren Olanow Название: Restorative Therapies in Parkinson`s Disease ISBN: 1489995226 ISBN-13(EAN): 9781489995223 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. The field of restorative therapies in Parkinson’s disease has passed the initial phase of pioneering experimental and clinical trials. There still does not exist restorative therapy that can be applied in large numbers of patients, but the initial trials have provided us with fundamental insight into the potential for plasticity in the diseased brain. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease.
Автор: Chaudhuri K Ray Название: Nonmotor Parkinson`s: The Hidden Face ISBN: 0128137088 ISBN-13(EAN): 9780128137086 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Поставка под заказ.
Описание:
Non-motor Parkinson's: The Many Hidden Faces, Volume 133, the first part of the latest volume in the International Review of Neurobiology series, is an up-to-date, comprehensive textbook addressing the non-motor aspects of Parkinson's disease, a key unmet need. Including practical tips for non-specialists and clinical algorithms, this book contains contributions from over 40 opinion leaders in the field of movement disorders, covering the topic from laboratory, to bedside, to caregiver.
Presents a comprehensive textbook on the non motor aspects of Parkinson's disease
Includes practical tips and clinical algorithms, and is the only textbook to bring a holistic approach
Contains contributions from over 40 global opinion leaders in the field of movement disorders
Provides special chapters on exercise, personalized medicine, osteoporosis, genetics, treatment aspects and nutrition
Non-motor Parkinson's: Management and Hidden Face of Related Disorders, Volume 134, the latest release in the International Review of Neurobiology series, is an up-to-date and comprehensive textbook addressing non-motor aspects of Parkinson's disease, a key unmet need. Including practical tips for no specialists and clinical algorithms, the book contains contributions from over 40 opinion leaders in the field of movement disorders. It provides practitioners and researchers with a laboratory, to bedside, to caregiver perspective.
Presents a comprehensive textbook on the non motor aspects of Parkinson's disease
Includes practical tips and clinical algorithms, and is the only textbook to bring a holistic approach
Contains contributions from over 40 global opinion leaders in the field of movement disorders
Provides special chapters on exercise, personalized medicine, osteoporosis, genetics, treatment aspects and nutrition
Автор: Susan H. Fox; Jonathan M. Brotchie Название: Levodopa-Induced Dyskinesia in Parkinson`s Disease ISBN: 1447165020 ISBN-13(EAN): 9781447165026 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from `bench to bedside`. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID.
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