Jak-Stat Signaling : From Basics to Disease, Thomas Decker; Mathias M?ller
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Автор: Andrew F. Wilks; Ailsa G. Harpur Название: Intracellular Signal Transduction: The JAK-STAT Pathway ISBN: 3662220520 ISBN-13(EAN): 9783662220528 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is the first one written about the JAK/STAT pathway. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself.
Автор: Ward Название: STAT Inhibitors in Cancer ISBN: 3319429477 ISBN-13(EAN): 9783319429472 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.
Автор: Coates Название: Dormancy and Low Growth States in Microbial Disease ISBN: 0521187842 ISBN-13(EAN): 9780521187848 Издательство: Cambridge Academ Рейтинг: Цена: 7128.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Many bacteria survive infection of their host in a low growth state, including the classic persistent infectious bacteria, tuberculosis. This 2003 book will interest microbiologists, medical microbiologists and infectious disease clinicians who are interested in learning more about the fundamental science of bacterial dormancy in relation to disease.
Автор: Mirko HH Schmidt; Stefan Liebner Название: Endothelial Signaling in Development and Disease ISBN: 1493929062 ISBN-13(EAN): 9781493929061 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Endothelial Signaling in Development and Disease
Описание: This monograph reports on advances in the measurement and study of autonomic nervous system dynamics. It demonstrates methods useful for engineers and computer scientists in increasing the ability of machines to monitor and recognize human emotional states.
Автор: Khalil Ahmed; Olaf-Georg Issinger; Ryszard Szyszka Название: Protein Kinase CK2 Cellular Function in Normal and Disease States ISBN: 3319145436 ISBN-13(EAN): 9783319145433 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
Автор: Alessandro Minelli Название: Biological Systematics: The State of the Art ISBN: 0412364409 ISBN-13(EAN): 9780412364402 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a critical overview of the state of the art in biological systematics and presents a broad perspective of the subject, covering its history, theory and practice. Emphasis is placed on the species concept and the methodology of phylogenetic reconstruction.
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