Circulating Nucleic Acids in Plasma and Serum, Peter B. Gahan

Автор: Peter B. Gahan
Название: Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring
ISBN: 9402402179 ISBN-13(EAN): 9789402402179
Издательство: Springer
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Цена: 19589.00 р.
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Описание:

DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids.

The areas covered in this volume include:

- Background and general biology of circulating nucleic acids

- Methodology

- Applications of circulating nucleic acids

- Quality Assurance

- Ethics

Автор: Michail Ignatiadis; Christos Sotiriou; Klaus Pante
Название: Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer
ISBN: 364244587X ISBN-13(EAN): 9783642445873
Издательство: Springer
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Цена: 27950.00 р.
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Описание: This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Автор: Peter Igaz
Название: Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
ISBN: 3034809530 ISBN-13(EAN): 9783034809535
Издательство: Springer
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Цена: 19564.00 р.
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Описание: MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.

Автор: Mark Jesus M. Magbanua; John W. Park
Название: Isolation and Molecular Characterization of Circulating Tumor Cells
ISBN: 331955946X ISBN-13(EAN): 9783319559469
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities.

Автор: Mark Jesus M. Magbanua; John W. Park
Название: Circulating Tumor Cells
ISBN: 1493971433 ISBN-13(EAN): 9781493971435
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This volume explores various approaches for enrichment, detection, isolation, and molecular profiling of circulating tumor cells (CTCs).

Автор: Nobuyoshi Kosaka
Название: Circulating MicroRNAs
ISBN: 149396299X ISBN-13(EAN): 9781493962990
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This Methods in Molecular Biology (TM) book covers the isolation, purification and analysis of circulating miRNAs from a variety of sources. Includes materials lists, reproducible laboratory protocols, key troubleshooting tips and advice on avoiding known pitfalls.

Автор: Nobuyoshi Kosaka
Название: Circulating MicroRNAs
ISBN: 1627034528 ISBN-13(EAN): 9781627034524
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This Methods in Molecular Biology (TM) book covers the isolation, purification and analysis of circulating miRNAs from a variety of sources. Includes materials lists, reproducible laboratory protocols, key troubleshooting tips and advice on avoiding known pitfalls.

Автор: Martin C. Woodle; Gerrit Storm
Название: Long Circulating Liposomes: Old Drugs, New Therapeutics
ISBN: 3662221179 ISBN-13(EAN): 9783662221174
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.

Автор: David W. Greening; Richard J. Simpson
Название: Serum/Plasma Proteomics
ISBN: 1493970569 ISBN-13(EAN): 9781493970568
Издательство: Springer
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Цена: 22359.00 р.
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Описание:

Part I Updated Blood Processing and Handling Strategies

1. Direct Assessment of Plasma/Serum Sample Quality for Proteomics Biomarker Investigation

Viviana Greco, Cristian Piras, Luisa Pieroni, and Andrea Urbani

2. A Protocol for the Preparation of Cryoprecipitate and Cryo-Depleted Plasma

Rosemary L Sparrow, David W Greening, and Richard J Simpson

3. A Proteomic Protocol for the Preparation of Platelet Concentrates

David W Greening, Richard J Simpson, and Rosemary L Sparrow

Part II Updated Fractionation Strategies for In-depth Blood Proteome Analysis

4. Bead-based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture

Elin Birgersson, Jochen M. Schwenk, and Burcu Ayoglu

Автор: Dmitry M. Kolpashchikov (Editor), Yulia V. Gerasim
Название: Nucleic Acid Detection: Methods and Protocols (Methods in Molecular Biology)
ISBN: 1627035346 ISBN-13(EAN): 9781627035347
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This Methods in Molecular Biology book details approaches for the detection of DNA and RNA including recovery of trace amounts of DNA for amplification and analysis, new qPCR chemistries, step-by-step, reproducible protocols, materials lists, tips and more.

Автор: JORGEN KJEMS, Elena Ferapontova, Kurt V. Gothelf
Название: Nucleic Acid Nanotechnology
ISBN: 3642388140 ISBN-13(EAN): 9783642388149
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This book surveys the intersection of nucleic acid research with nanotechnology, including advances in synthetic modifications, applications in bioengineering, nanoscale design, medicine, genetic analysis, chemistry, molecular biology and material science.

Автор: Jason X. -J. Yuan; Jeremy P. T. Ward
Название: Membrane Receptors, Channels and Transporters in Pulmonary Circulation
ISBN: 1627038256 ISBN-13(EAN): 9781627038256
Издательство: Springer
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Цена: 46118.00 р.
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Описание: Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.