Описание: Lecture Notes: Clinical Pharmacology & Therapeutics is the core text for medical students, junior doctors, students in nursing, dentistry and pharmacy, general practitioners and allied health professionals who want a concise introduction to the subject of clinical pharmacology and the latest information on new and withdrawn drugs.
Описание: This book covers the current state of knowledge of the adenosine A3 receptor. Coverage includes data from studies of theoretical, molecular, and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications.
Описание: This text contains lectures which cover a range of subjects from molecular and cellular biology to clinical applications. Emphasis has been placed on information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research.
Автор: Constance N. Wilson; S. Jamal Mustafa Название: Adenosine Receptors in Health and Disease ISBN: 3662501627 ISBN-13(EAN): 9783662501627 Издательство: Springer Рейтинг: Цена: 65305.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Adenosine receptors are important novel molecular targets in disease and drug discovery. As a result of investigations into these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials.
Описание: This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication.
Автор: Robert M. Mentzer Jr.; Masafumi Kitakaze; James M. Название: Adenosine, Cardioprotection and Its Clinical Application ISBN: 0792399544 ISBN-13(EAN): 9780792399544 Издательство: Springer Рейтинг: Цена: 24456.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The immense growth in the number of articles on adenosine cardioprotection has been related in large part to the hypothesis that adenosine plays a role in ischemic preconditioning. This title discusses different aspects of adenosine cardioprotection and ischemic preconditioning, including potential mechanisms and clinical applications.
Автор: Robert M. Berne; Theodore W. Rall; Rafael Rubio Название: Regulatory Function of Adenosine ISBN: 9024727790 ISBN-13(EAN): 9789024727797 Издательство: Springer Рейтинг: Цена: 45979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The principal objective of this symposium was to bring together investigators from all over the world who work in diverse areas of research but share a common interest in the physiologic and pathophysiologic funetions of the nueleoside adenosine. In 1978, the "International Conference on Physiological and Regulatory Funetions of Adenosine and Adenine Nueleotides," held in Banff, Canada, served as an effective catalyst in enabling scientists with differ- ent points of view to exchange information and ideas on this subject. Since 1978, the amount of research on different as peets of adenosine metabolism, mechanism of action, transport, and function in various tissues (in both nor- maI and abnormal states) has increased exponentially, and there was an urgent need for another meeting for updating information on this burgeoning subject. The focus of the meeting was extremely sharp, but the scope of the subject material was very broad. Scientists categorized as chemists, biochemists, physiologists, pharmacologists, and immunologists, working with cells and eelI fragments, with tissues such as heart, brain, musele, fat, kidney, and with human beings having immune deficiency diseases participated in the sym- posium. They had an opportunity to air their differences, reinforce their areas of agreement, and, most important, they educated each other with respeet to research on adenosine; it is hoped that they also enriched their own research programs from the information they gained from their fellow participants.
Автор: Robert M. Mentzer Jr.; Masafumi Kitakaze; James M. Название: Adenosine, Cardioprotection and Its Clinical Application ISBN: 1461346762 ISBN-13(EAN): 9781461346760 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: David Paton Название: Methods Used in Adenosine Research ISBN: 1468448889 ISBN-13(EAN): 9781468448887 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In their classic paper in 1929, Drury and Szent-Gyorgyi described a number of the important cardiovascular actions of adenosine.
Описание: A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Описание: Early approaches towards an understanding of transport at the tonoplast of higher plant cells were based on the kinetics of radio-isotope uptake (Torii and Laties. 1966) and exchange (Pitman, 1963). A variety of other methods became available in due course (reviewed by Clarkson and Luttge, 1984). But even with the most modern developments, the function of. the tonoplast remained in the dark. On the basis of Hitchell's chemiosmotic $heory (Hitchell, 1967), mechanisms of membrane-bound H -translocating ATPases and H -solute co-transport were conceived for the plasmalemma of fungi and plants, based on experiments with intact tissues, cells or protoplasts . With the onset of the era of membrane fractionation it seemed obvious that plasmalemma and tonoplast vlould cause the greatest problems due to the apparent lack of intrinsic markers. Again the situation for the plasmalemma appeared to be favorable; the periodic-phosphotungstic-acid reagent was considered as a specific stain. There was also the opportunity to bind externally applied markers to the plasmalemma prior to cell homogenization. Vacuoles were initially considered as compartments for intracellular excretion or at best as storage compart- ments, but were later understood to have important dynamic functions in cell physiology as a lytic compart- ment comparable to animal lysosomes (Hatile, 1966). The dynamics of molecular functions of the tonoplast itself remained obscure, however, with one exception. Hotivated by the search for a better understanding of latex production by the rubber tree Hevea brasiliensis Hull. -Arg.
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