Advances in Biology and Therapy of Multiple Myeloma, Nikhil C. Munshi; Kenneth C. Anderson

Автор: Nikhil C. Munshi; Kenneth C. Anderson
Название: Advances in Biology and Therapy of Multiple Myeloma
ISBN: 1489989145 ISBN-13(EAN): 9781489989147
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

Автор: Schey
Название: Myeloma
ISBN: 1107010578 ISBN-13(EAN): 9781107010574
Издательство: Cambridge Academ
Рейтинг:
Цена: 9979.00 р.
Наличие на складе: Поставка под заказ.

Описание: Myeloma is the second-most common hematologic cancer, accounting for approximately 1 percent of all cancers and 2 percent of all deaths from cancer. In recent years there have been major and significant advances in the diagnosis, imaging, molecular pathogenesis, and therapy of myeloma. This book describes these advances in a single, practical volume, placing them in the context of daily clinical practice. Different myeloma subtypes are discussed in individual chapters, integrating etiology, pathogenesis, molecular pathology, histology, and therapy in a single place for each condition. The book begins by discussing epidemiology, imaging techniques, pathogenesis, and other general considerations. Conditions covered in detail include multiple myeloma, POEMS syndrome, Castleman's syndrome, Waldenstrom's macroglobulinemia, amyloidosis and MGUS. Featuring color illustrations, and written and edited by leading authorities in the field, Myeloma provides readers with the information they need to diagnose and manage these complex disorders.

Автор: G. Iris Obrams; Michael Potter
Название: Epidemiology and Biology of Multiple Myeloma
ISBN: 3642766579 ISBN-13(EAN): 9783642766572
Издательство: Springer
Рейтинг:
Цена: 15372.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health.

Название: Multiple Myeloma and Related Disorders
ISBN: 0340810106 ISBN-13(EAN): 9780340810101
Издательство: Taylor&Francis
Рейтинг:
Цена: 42874.00 р.
Наличие на складе: Поставка под заказ.

Описание: During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals

Автор: Thomas Moehler; Hartmut Goldschmidt
Название: Multiple Myeloma
ISBN: 3642267998 ISBN-13(EAN): 9783642267994
Издательство: Springer
Рейтинг:
Цена: 32004.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable.

Автор: Gertz
Название: Multiple Myeloma
ISBN: 1461485193 ISBN-13(EAN): 9781461485193
Издательство: Springer
Рейтинг:
Цена: 19564.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders.

Название: Handbook of multiple myeloma
ISBN: 331918217X ISBN-13(EAN): 9783319182179
Издательство: Springer
Рейтинг:
Цена: 9083.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma.