Epidemiology and Biology of Multiple Myeloma, G. Iris Obrams; Michael Potter
Автор: Suzanne Lentzsch Название: Genetic and Molecular Epidemiology of Multiple Myeloma ISBN: 1489998659 ISBN-13(EAN): 9781489998651 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This exploration of the role of protein translation in multiple myeloma covers recent advances in oncogenomic research that further our understanding of the disease`s molecular pathogenesis, and discusses the emerging technique of epigenetic gene silencing.
Название: Handbook of multiple myeloma ISBN: 331918217X ISBN-13(EAN): 9783319182179 Издательство: Springer Рейтинг: Цена: 9083.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma.
Автор: Schey Название: Myeloma ISBN: 1107010578 ISBN-13(EAN): 9781107010574 Издательство: Cambridge Academ Рейтинг: Цена: 9979.00 р. Наличие на складе: Поставка под заказ.
Описание: Myeloma is the second-most common hematologic cancer, accounting for approximately 1 percent of all cancers and 2 percent of all deaths from cancer. In recent years there have been major and significant advances in the diagnosis, imaging, molecular pathogenesis, and therapy of myeloma. This book describes these advances in a single, practical volume, placing them in the context of daily clinical practice. Different myeloma subtypes are discussed in individual chapters, integrating etiology, pathogenesis, molecular pathology, histology, and therapy in a single place for each condition. The book begins by discussing epidemiology, imaging techniques, pathogenesis, and other general considerations. Conditions covered in detail include multiple myeloma, POEMS syndrome, Castleman's syndrome, Waldenstrom's macroglobulinemia, amyloidosis and MGUS. Featuring color illustrations, and written and edited by leading authorities in the field, Myeloma provides readers with the information they need to diagnose and manage these complex disorders.
Автор: Nikhil C. Munshi; Kenneth C. Anderson Название: Advances in Biology and Therapy of Multiple Myeloma ISBN: 1489989994 ISBN-13(EAN): 9781489989994 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Multiple myeloma remains incurable, immune to developments in cancer treatment such as high-dose chemotherapy and new kinds of agents. This volume assesses new approaches currently being developed that overcome drug resistance and improve patient outcomes.
Автор: Nikhil C. Munshi; Kenneth C. Anderson Название: Advances in Biology and Therapy of Multiple Myeloma ISBN: 1489989145 ISBN-13(EAN): 9781489989147 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Автор: James R. Berenson Название: Biology and Management of Multiple Myeloma ISBN: 1617371432 ISBN-13(EAN): 9781617371431 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Expert physicians and clinical researchers summarize and explain all the recent advances in the biology and treatment of bone marrow-based malignancy.
Автор: Brown Название: Multiple Myeloma ISBN: 1617375373 ISBN-13(EAN): 9781617375378 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Offers a comprehensive collection of classic and innovative methodologies used in many laboratories for the investigation of multiple myeloma. This title offers readily reproducible techniques that range from the standard Plasma Cell Labeling Index methodology to a final chapter on making sense of microarrays.
