DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids.
The areas covered in this volume include:
- Background and general biology of circulating nucleic acids
- Methodology
- Applications of circulating nucleic acids
- Quality Assurance
- Ethics
Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar Название: Chemical Biology of Nucleic Acids ISBN: 3662513242 ISBN-13(EAN): 9783662513248 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids.
Автор: Lawrence J. Berliner; Jacques Reuben Название: Carbohydrates and Nucleic Acids ISBN: 1475794762 ISBN-13(EAN): 9781475794762 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the past ten years or so, biological magnetic resonance (NMR and ESR) has fully blossomed and become highly branched. Thus, those who investigate protein structure by multi- dimensional NMR spectroscopy do not usually engage in studies involving in vivo spectroscopy.
Автор: Neidle, Stephen Название: Therapeutic Applications of Quadruplex Nucleic Acids ISBN: 0128103728 ISBN-13(EAN): 9780128103722 Издательство: Elsevier Science Рейтинг: Цена: 15327.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligandsand the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies.Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics.Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.
Автор: Peter Baumann Название: G-Quadruplex DNA ISBN: 1493956396 ISBN-13(EAN): 9781493956395 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this authoritative book, experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. It provides detailed protocols which ensure successful re-recreation of experimental procedures.
Автор: JORGEN KJEMS, Elena Ferapontova, Kurt V. Gothelf Название: Nucleic Acid Nanotechnology ISBN: 3642388140 ISBN-13(EAN): 9783642388149 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book surveys the intersection of nucleic acid research with nanotechnology, including advances in synthetic modifications, applications in bioengineering, nanoscale design, medicine, genetic analysis, chemistry, molecular biology and material science.
Автор: U. Jensen; D.E. Fairbrothers Название: Proteins and Nucleic Acids in Plant Systematics ISBN: 3642692893 ISBN-13(EAN): 9783642692895 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The continued rapid expansion of molecular biology, genetics, and macromolecular biochemistry has provided significant data for ana- lyses, interpretations, and incorporation into plant phylogenetic re- search and plant classification. These disciplines have produced techni- ques and methods which enable the evolutionary biologists to obtain new and provocative information, especially about those substances which are coupled with the genetic material. In July, 1982 these im- portant biochemical substances extracted from living plant organs, tis- sues or cells were the subject of an International Symposium held at the University of Bayreuth, Federal Republic of Germany, entitled Proteins and Nucleic Acids in Plant Systematics. At this Symposium German scientists communicated with leading scientists from eleven other countries. The Deutsche Forschungsgemeinschaft generously supported this symposium and thus enabled the exchange of data, ideas, and new scientific proposals. This book contains 26 contribu- tions delivered at the Symposium, which review the present status of Plant Macromolecular Systematics. The two editors acknowledge the effort of the Springer Verlag and their indispensable help with the preparation of this publication. Bayreuth, FRG and U. JENSEN and New Brunswick, NJ, USA D. E. FAIRBROTHERS November 1983 Contents Nucleic Acids Quantitative and Qualitative Differentiation ofNuclear DNA in Relation to Plant Systematics and Evolution F. EHRENDORFER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Phylogenetic Significance of Nucleotide Sequence Analysis H. KOSSEL, K. EDWARDS, E. FRITZSCHE, W. KOCH, and Zs. SCHWARZ. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 Comparative Oligonucleotide Cataloguing of 18 S Ribosomal RNA in Phylogenetic Studies of Eukaryotes L. STOCKLEIN, W. LUDWlG, K. H. SCHLEIFER, and E. STACKEBRANDT. . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Автор: Keith R. Mitchelson; Jing Cheng Название: Capillary Electrophoresis of Nucleic Acids ISBN: 1617371866 ISBN-13(EAN): 9781617371868 Издательство: Springer Рейтинг: Цена: 26552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical procedures that permit use of this new resource for the analysis of genetic variation and for the detection of disease-causing mutations.
Автор: Lawrence J. Berliner; Jacques Reuben Название: Carbohydrates and Nucleic Acids ISBN: 0306440601 ISBN-13(EAN): 9780306440601 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the past ten years or so, biological magnetic resonance (NMR and ESR) has fully blossomed and become highly branched. Thus, those who investigate protein structure by multi- dimensional NMR spectroscopy do not usually engage in studies involving in vivo spectroscopy.
Автор: Valery N. Soyfer; Vladimir N. Potaman Название: Triple-Helical Nucleic Acids ISBN: 1461284546 ISBN-13(EAN): 9781461284543 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc.
Автор: Manoj Shukla; Jerzy Leszczynski Название: Radiation Induced Molecular Phenomena in Nucleic Acids ISBN: 9048177979 ISBN-13(EAN): 9789048177974 Издательство: Springer Рейтинг: Цена: 64148.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Comprehensive theoretical and experimental analysis of UV-radiation and low energy electron induced phenomena in nucleic acid bases (NABs) and base assemblies are presented in this book.
Автор: L. Bogorad Название: Nucleic Acids and Protein Synthesis in Plants ISBN: 1468427776 ISBN-13(EAN): 9781468427776 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During the summer of 1974 we discussed the state of molecular biology and biochemical developmental biology in plants on a few occasions in Paris and in Strasbourg. The lectures published here* reflect the diversity of current research in plant molecular biology and biochemical developmental biology.
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