Chemical Biology of Nucleic Acids, Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642465986 ISBN-13(EAN): 9783642465987 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar Название: Chemical Biology of Nucleic Acids ISBN: 3642544517 ISBN-13(EAN): 9783642544514 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
Описание: This Methods in Molecular Biology book details approaches for the detection of DNA and RNA including recovery of trace amounts of DNA for amplification and analysis, new qPCR chemistries, step-by-step, reproducible protocols, materials lists, tips and more.
Автор: Jurga Название: Modified Nucleic Acids in Biology and Medicine ISBN: 3319341731 ISBN-13(EAN): 9783319341736 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642837115 ISBN-13(EAN): 9783642837111 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642779522 ISBN-13(EAN): 9783642779527 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biology is one of the most rapidly growing develo-ping and at thesame time most exciting disciplines. Nucleic Acids and Molecular Biology keeps scientistsinformed of the explosively growing information and complieswith with the great interest in this field by offering acontinued high standard of review.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642773583 ISBN-13(EAN): 9783642773587 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biology is one of the most rapidly growingdeveloping and at the same time most exciting disciplines. Nucleic Acids in Molecular Biology keepsscientists informed of the explosively growing informationand complies with the great interest in this field byoffering a continued high standard of review.
Автор: Fritz Eckstein Eckstein Название: Nucleic Acids and Molecular Biology ISBN: 3642794904 ISBN-13(EAN): 9783642794902 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins.Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642833861 ISBN-13(EAN): 9783642833861 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biology has always been a discipline of rapid development. The rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology ISBN: 3642786685 ISBN-13(EAN): 9783642786686 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins.Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review.
Автор: Fritz Eckstein; David M. J. Lilley Название: Nucleic Acids and Molecular Biology 4 ISBN: 364284152X ISBN-13(EAN): 9783642841521 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. Nucleic Acids and Molecular Biology was created to keep scientists abreast of the explosively growing information and to comply with the great interest in this field.
Автор: JORGEN KJEMS, Elena Ferapontova, Kurt V. Gothelf Название: Nucleic Acid Nanotechnology ISBN: 3642388140 ISBN-13(EAN): 9783642388149 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book surveys the intersection of nucleic acid research with nanotechnology, including advances in synthetic modifications, applications in bioengineering, nanoscale design, medicine, genetic analysis, chemistry, molecular biology and material science.
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