The Hippo Signaling Pathway and Cancer, Moshe Oren; Yael Aylon
Àâòîð: Gerard P. Zambetti Íàçâàíèå: The p53 Tumor Suppressor Pathway and Cancer ISBN: 1489998799 ISBN-13(EAN): 9781489998798 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 26120.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells.
Àâòîð: Kathleen H. Goss; Michael Kahn Íàçâàíèå: Targeting the Wnt Pathway in Cancer ISBN: 1489981640 ISBN-13(EAN): 9781489981646 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 23757.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of ?-catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Àâòîð: Moshe Oren; Yael Aylon Íàçâàíèå: The Hippo Signaling Pathway and Cancer ISBN: 1461462193 ISBN-13(EAN): 9781461462194 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 26122.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: � � This book � explores virtually all aspects of tumor biology in relation to the Hippo Pathway. It gathers wide-ranging and burgeoning information into an accessible format and features timely research from leading scientists in the field.
Àâòîð: Vitaly A. Polunovsky; Peter J. Houghton Íàçâàíèå: mTOR Pathway and mTOR Inhibitors in Cancer Therapy ISBN: 1617796948 ISBN-13(EAN): 9781617796944 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 28732.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).
Îïèñàíèå: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.
Àâòîð: Adam B. Glick; Carter Van Waes Íàçâàíèå: Signaling Pathways in Squamous Cancer ISBN: 1489982345 ISBN-13(EAN): 9781489982346 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 30745.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.
Àâòîð: Andrew F. Wilks; Ailsa G. Harpur Íàçâàíèå: Intracellular Signal Transduction: The JAK-STAT Pathway ISBN: 3662220520 ISBN-13(EAN): 9783662220528 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 15672.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: This book is the first one written about the JAK/STAT pathway. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself.
Àâòîð: David A. Frank Íàçâàíèå: Signaling Pathways in Cancer Pathogenesis and Therapy ISBN: 1489992227 ISBN-13(EAN): 9781489992222 Èçäàòåëüñòâî: Springer Ðåéòèíã: Öåíà: 16977.00 ð. Íàëè÷èå íà ñêëàäå: Åñòü ó ïîñòàâùèêà Ïîñòàâêà ïîä çàêàç.
Îïèñàíèå: This book describes research suggesting that abnormal activation of signaling pathways is a critical event in cancer pathogenesis, and describes the emerging ability to design small molecules, protein therapeutics, and other forms of targeted cancer therapies.
Îïèñàíèå: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.
Îïèñàíèå: This book covers all aspects of CD137/4-1BB pathway research. This pathway is emerging as one of the most important targets for manipulation of immune responses for disease diagnosis and treatment. The book`s author discovered the CD-137 and B7H1 molecules in 1999.
