Описание: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.
Автор: Magnani Mauro Название: Erythrocyte Engineering for Drug Delivery and Targeting ISBN: 0306476916 ISBN-13(EAN): 9780306476914 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Includes topics such as electrochemical nuclear magnetic resonance (EC-NMR), the advances in the use of ab initio quantum chemical calculations in electrochemistry, the macroscopic and statistical thermodynamic models developed to describe adsorption phenomena on electrodes, and electrochemical promotion. This volume contains research results on plant lipids,including their structure, analysis, biosynthesis, regulation, physiological function, environmental aspects, and biotechnology, obtained world-wide during 2000-2002.
Автор: Steven Kanner Название: Tumor Metabolome Targeting and Drug Development ISBN: 1493953435 ISBN-13(EAN): 9781493953431 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.
Автор: Vladimir R. Muzykantov; Vladimir P. Torchilin Название: Biomedical Aspects of Drug Targeting ISBN: 1441953124 ISBN-13(EAN): 9781441953124 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results in low efficiency and unwanted side effects.
Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.
Описание: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.
Описание: Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to "molecules and cells that negatively regulate T-cell activation".
Автор: Yang Название: Targeting Autophagy in Cancer Therapy ISBN: 3319427385 ISBN-13(EAN): 9783319427386 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research.This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
Автор: Eleonora Patsenker Название: Integrin Targeting Systems for Tumor Diagnosis and Therapy ISBN: 1493974432 ISBN-13(EAN): 9781493974436 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular.
Автор: Pardridge Название: Brain Drug Targeting. Vol 34. ISBN: 0521800773 ISBN-13(EAN): 9780521800778 Издательство: Cambridge Academ Рейтинг: Цена: 27562.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The thesis of this innovative and challenging book, first published in 2001, is that brain drug development has been restricted by the failure of adequate brain drug targeting, and that this is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author, a world leader in the study of the blood-brain barrier and its clinical implications, reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.
Автор: Steven Kanner Название: Tumor Metabolome Targeting and Drug Development ISBN: 146149544X ISBN-13(EAN): 9781461495444 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.
Автор: Gregory Gregoriadis; Brenda McCormack; George Post Название: Targeting of Drugs 4 ISBN: 0306449102 ISBN-13(EAN): 9780306449109 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1993
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