Описание: This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It offers a comparative analysis of models based on geometry versus those based on knowledge of the biological phenomenon.
Автор: Istvan Ladunga Название: Computational Biology of Transcription Factor Binding ISBN: 1493961667 ISBN-13(EAN): 9781493961665 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Transcriptional regulation controls the basic processes of life. Its complex, dynamic, and hierarchical networks control the momentary availability of messenger RNAs for protein synthesis. Transcriptional regulation is key to cell division, development, tissue differen- ation, and cancer as discussed in Chapters 1 and 2. We have witnessed rapid, major developments at the intersection of computational biology, experimental technology, and statistics. A decade ago, researches were struggling with notoriously challenging predictions of isolated binding sites from low-throughput experiments. Now we can accurately predict cis-regulatory modules, conserved cl- ters of binding sites (Chapters 13 and 15), partly based on high-throughput ch- matin immunoprecipitation experiments in which tens of millions of DNA segments are sequenced by massively parallel, next-generation sequencers (ChIP-seq, Chapters 9, 10, and 11). These spectacular developments have allowed for the genome-wide mappings of tens of thousands of transcription factor binding sites in yeast, bacteria, mammals, insects, worms, and plants. Please also note the no less spectacular failures in many laboratories around the world.
Автор: Johannes A. Elbe Название: Integrin-Ligand Interaction ISBN: 1475740662 ISBN-13(EAN): 9781475740660 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: When James Meredith enrolled as the first African American student at the University of Mississippi in 1962, the resulting riots produced more casualties than any other clash of the civil rights era. Eagles shows that the violence resulted from the university`s and the state`s long defiance of the civil rights movement and federal law. Eagles also paints a remarkable portrait of Meredith himself.
Автор: Mark A. Williams; Tina Daviter Название: Protein-Ligand Interactions ISBN: 1493958739 ISBN-13(EAN): 9781493958733 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In its revised 2nd Edition, this Methods in Molecular Biology (TM) book provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. Offers materials lists, reproducible protocols, notes and more.
Автор: W. Guschlbauer Название: DNA-Ligand Interactions ISBN: 1468453858 ISBN-13(EAN): 9781468453850 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.
Автор: Mark A. Williams; Tina Daviter Название: Protein-Ligand Interactions ISBN: 1627033971 ISBN-13(EAN): 9781627033978 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In its revised 2nd Edition, this Methods in Molecular Biology (TM) book provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. Offers materials lists, reproducible protocols, notes and more.
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