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Computational Biology of Transcription Factor Binding, Istvan Ladunga


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Автор: Istvan Ladunga
Название:  Computational Biology of Transcription Factor Binding
ISBN: 9781493961665
Издательство: Springer
Классификация:


ISBN-10: 1493961667
Обложка/Формат: Paperback
Страницы: 454
Вес: 0.88 кг.
Дата издания: 23.08.2016
Серия: Methods in Molecular Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 23 tables, black and white; xi, 454 p.
Размер: 254 x 178 x 24
Читательская аудитория: General (us: trade)
Основная тема: Life Sciences
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Transcriptional regulation controls the basic processes of life. Its complex, dynamic, and hierarchical networks control the momentary availability of messenger RNAs for protein synthesis. Transcriptional regulation is key to cell division, development, tissue differen- ation, and cancer as discussed in Chapters 1 and 2. We have witnessed rapid, major developments at the intersection of computational biology, experimental technology, and statistics. A decade ago, researches were struggling with notoriously challenging predictions of isolated binding sites from low-throughput experiments. Now we can accurately predict cis-regulatory modules, conserved cl- ters of binding sites (Chapters 13 and 15), partly based on high-throughput ch- matin immunoprecipitation experiments in which tens of millions of DNA segments are sequenced by massively parallel, next-generation sequencers (ChIP-seq, Chapters 9, 10, and 11). These spectacular developments have allowed for the genome-wide mappings of tens of thousands of transcription factor binding sites in yeast, bacteria, mammals, insects, worms, and plants. Please also note the no less spectacular failures in many laboratories around the world.
Дополнительное описание: An Overview of the Computational Analyses and Discovery of Transcription Factor Binding Sites.- Components and Mechanisms of Regulation of Gene Expression.- Regulatory Regions in DNA: Promoters, Enhancers, Silencers, and Insulators.- Three-Dimensional Str



Differential-Display Reverse Transcription-PCR (DDRT-PCR)

Автор: Sergio Colonna-Romano; Antonella Leone; Bruno Mare
Название: Differential-Display Reverse Transcription-PCR (DDRT-PCR)
ISBN: 3540632972 ISBN-13(EAN): 9783540632979
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Identification of differentially expressed genes is one of the major challenges in molecular biology. This technique has been proven to be highly effective in identifying sequences that are differentially expressed in various cell types.

Transcription Factors

Автор: Manfred Gossen; J?rg Kaufmann; Steven J. Triezenbe
Название: Transcription Factors
ISBN: 3642623611 ISBN-13(EAN): 9783642623615
Издательство: Springer
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Цена: 41925.00 р.
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Описание: With contributions by numerous experts

DNA Conformation and Transcription

Автор: Takashi Ohyama
Название: DNA Conformation and Transcription
ISBN: 1489995072 ISBN-13(EAN): 9781489995070
Издательство: Springer
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Цена: 23757.00 р.
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Описание:

Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.

We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle 'written' in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code."

RNA Polymerase III Transcription

Автор: Robert J. White
Название: RNA Polymerase III Transcription
ISBN: 3662035200 ISBN-13(EAN): 9783662035207
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This monograph reviews and summarizes the substantial body of work that has been published on the transcription by polymerase III over the past 5 years.

Computational Design of Ligand Binding Proteins

Автор: Barry L. Stoddard
Название: Computational Design of Ligand Binding Proteins
ISBN: 1493935674 ISBN-13(EAN): 9781493935673
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume provides acollection of protocols and approaches for the creation of novel ligand bindingproteins, compiled and described by many of today`s leaders in the field ofprotein engineering.

Post-Transcriptional Gene Regulation

Автор: Jeffrey Wilusz
Название: Post-Transcriptional Gene Regulation
ISBN: 1617377767 ISBN-13(EAN): 9781617377761
Издательство: Springer
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Цена: 20263.00 р.
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Описание: With chapters split into sections covering bioinformatics, fundamental aspects of the study of RNA biology, and techniques for specific aspects of RNA biology, the expert authors have filled the book with invaluable tricks of the trade, perfected in their laboratories.

Mechanisms of Transcription

Автор: Fritz Eckstein; David M.J. Lilley
Название: Mechanisms of Transcription
ISBN: 3642645097 ISBN-13(EAN): 9783642645099
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.

Signalling Mechanisms — from Transcription Factors to Oxidative Stress

Автор: Lester Packer; Karel W.A. Wirtz
Название: Signalling Mechanisms — from Transcription Factors to Oxidative Stress
ISBN: 364279677X ISBN-13(EAN): 9783642796777
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Proceedings of the NATO Advances Study Institute on Molecular Mechanisms of Transcellular Signalling: from the Membrane to the Gene, held at the Island of Spetses, Greece, August 15-27, 1994

Post-transcriptional Control of Gene Expression

Автор: Orna Resnekov; Alexander von Gabain
Название: Post-transcriptional Control of Gene Expression
ISBN: 3642646093 ISBN-13(EAN): 9783642646096
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Many important cellular processes rely on posttranscriptional control of gene expression. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed.


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