Описание: Proceedings of the NATO Advances Study Institute on Molecular Mechanisms of Transcellular Signalling: from the Membrane to the Gene, held at the Island of Spetses, Greece, August 15-27, 1994
Автор: Takashi Ohyama Название: DNA Conformation and Transcription ISBN: 1489995072 ISBN-13(EAN): 9781489995070 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle 'written' in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code."
Описание: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.
Автор: Sergio Colonna-Romano; Antonella Leone; Bruno Mare Название: Differential-Display Reverse Transcription-PCR (DDRT-PCR) ISBN: 3540632972 ISBN-13(EAN): 9783540632979 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Identification of differentially expressed genes is one of the major challenges in molecular biology. This technique has been proven to be highly effective in identifying sequences that are differentially expressed in various cell types.
Автор: Istvan Ladunga Название: Computational Biology of Transcription Factor Binding ISBN: 1493961667 ISBN-13(EAN): 9781493961665 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Transcriptional regulation controls the basic processes of life. Its complex, dynamic, and hierarchical networks control the momentary availability of messenger RNAs for protein synthesis. Transcriptional regulation is key to cell division, development, tissue differen- ation, and cancer as discussed in Chapters 1 and 2. We have witnessed rapid, major developments at the intersection of computational biology, experimental technology, and statistics. A decade ago, researches were struggling with notoriously challenging predictions of isolated binding sites from low-throughput experiments. Now we can accurately predict cis-regulatory modules, conserved cl- ters of binding sites (Chapters 13 and 15), partly based on high-throughput ch- matin immunoprecipitation experiments in which tens of millions of DNA segments are sequenced by massively parallel, next-generation sequencers (ChIP-seq, Chapters 9, 10, and 11). These spectacular developments have allowed for the genome-wide mappings of tens of thousands of transcription factor binding sites in yeast, bacteria, mammals, insects, worms, and plants. Please also note the no less spectacular failures in many laboratories around the world.
Автор: Fritz Eckstein; David M.J. Lilley Название: Mechanisms of Transcription ISBN: 3642645097 ISBN-13(EAN): 9783642645099 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.
Автор: Robert J. White Название: RNA Polymerase III Transcription ISBN: 3662035200 ISBN-13(EAN): 9783662035207 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This monograph reviews and summarizes the substantial body of work that has been published on the transcription by polymerase III over the past 5 years.
Автор: Jeffrey Wilusz Название: Post-Transcriptional Gene Regulation ISBN: 1617377767 ISBN-13(EAN): 9781617377761 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With chapters split into sections covering bioinformatics, fundamental aspects of the study of RNA biology, and techniques for specific aspects of RNA biology, the expert authors have filled the book with invaluable tricks of the trade, perfected in their laboratories.
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