T-type Calcium Channels in Basic and Clinical Science, Stephen W. Schaffer; Ming Li

Автор: Stephen W. Schaffer; Ming Li
Название: T-type Calcium Channels in Basic and Clinical Science
ISBN: 3709114128 ISBN-13(EAN): 9783709114124
Издательство: Springer
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Цена: 19564.00 р.
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Описание: T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.

Автор: Stephens Gary
Название: Modulation of Presynaptic Calcium Channels
ISBN: 9400763336 ISBN-13(EAN): 9789400763333
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book presents recent advances in knowledge of the regulation of presynaptic Ca2+ channels. These represent one of the most widely modulated proteins in the body, target of a range of effector pathways and drugs; this range will be fully represented here.

Автор: Gerald Werner Zamponi
Название: Voltage-Gated Calcium Channels
ISBN: 1441934111 ISBN-13(EAN): 9781441934116
Издательство: Springer
Цена: 28732.00 р.
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Описание: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl- edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac- tivity, the book delves into a provocative overview of the history of the cal- cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat- ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.

Автор: Norbert Weiss; Alexandra Koschak
Название: Pathologies of Calcium Channels
ISBN: 364240281X ISBN-13(EAN): 9783642402814
Издательство: Springer
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Цена: 26122.00 р.
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Описание: Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.

Автор: Norbert Weiss; Alexandra Koschak
Название: Pathologies of Calcium Channels
ISBN: 3662523531 ISBN-13(EAN): 9783662523537
Издательство: Springer
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Цена: 22201.00 р.
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Описание: Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.

Автор: Kirk L. Hamilton; Daniel C Devor
Название: Ion Channels and Transporters of Epithelia in Health and Disease
ISBN: 1493933647 ISBN-13(EAN): 9781493933648
Издательство: Springer
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Цена: 34937.00 р.
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Описание: This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters.