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Gene Therapy and Cell Therapy Through the Liver, Shuji Terai; Takeshi Suda


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Автор: Shuji Terai; Takeshi Suda
Название:  Gene Therapy and Cell Therapy Through the Liver
ISBN: 9784431562511
Издательство: Springer
Классификация:



ISBN-10: 4431562516
Обложка/Формат: Paperback
Страницы: 185
Вес: 0.31 кг.
Дата издания: 23.08.2016
Язык: English
Издание: Softcover reprint of
Иллюстрации: 17 tables, black and white; x, 185 p.
Размер: 234 x 156 x 11
Читательская аудитория: General (us: trade)
Основная тема: Medicine & Public Health
Подзаголовок: Current Aspects and Future Prospects
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies.


Mesenchymal Stem Cell Therapy

Автор: Lucas G. Chase; Mohan C Vemuri
Название: Mesenchymal Stem Cell Therapy
ISBN: 1627039147 ISBN-13(EAN): 9781627039147
Издательство: Springer
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Цена: 21661.00 р.
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Описание: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Gene Therapy of Solid Cancers

Автор: Wolfgang Walther; Ulrike Stein
Название: Gene Therapy of Solid Cancers
ISBN: 1493927264 ISBN-13(EAN): 9781493927265
Издательство: Springer
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Цена: 15372.00 р.
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Emerging Trends in Cell and Gene Therapy

Автор: Michael K. Danquah; Ram I. Mahato
Название: Emerging Trends in Cell and Gene Therapy
ISBN: 1493962930 ISBN-13(EAN): 9781493962938
Издательство: Springer
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Цена: 25155.00 р.
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Описание: Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry. Main features of the book: · Biological aspects of stem cell sources, differentiation and engineering. · Application of microfluidics to study stem cell dynamics · Potential clinical application of stem cells and gene therapy to specific human disease. · Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. · Biomimetic multiscale topography for cell alignment.

Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy

Автор: W. Holzgreve; M. Lessl
Название: Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy
ISBN: 3662044714 ISBN-13(EAN): 9783662044711
Издательство: Springer
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Цена: 13974.00 р.
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Описание: The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop- ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop.

Stem Cell and Gene Therapy for Cardiovascular Disease

Автор: Emerson C. Perin
Название: Stem Cell and Gene Therapy for Cardiovascular Disease
ISBN: 0128018887 ISBN-13(EAN): 9780128018880
Издательство: Elsevier Science
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Цена: 17517.00 р.
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Описание:

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic.

As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials.

Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.

Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases

Автор: Nicole I. Nieden
Название: Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases
ISBN: 1493957236 ISBN-13(EAN): 9781493957231
Издательство: Springer
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Цена: 20263.00 р.
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Описание: In this dependable and cutting-edge book, accomplished investigators provide detailed descriptions on how to expand ESCs from the most commonly used species ex vivo, i.e. mouse and human, in static culture as well as in controllable bioreactor processes.

Stem Cells and Cell Therapy

Автор: Mohamed Al-Rubeai; Mariam Naciri
Название: Stem Cells and Cell Therapy
ISBN: 9402402187 ISBN-13(EAN): 9789402402186
Издательство: Springer
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Цена: 16977.00 р.
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Описание: It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products.

Emerging Trends in Cell and Gene Therapy

Автор: Michael K. Danquah; Ram I. Mahato
Название: Emerging Trends in Cell and Gene Therapy
ISBN: 1627034161 ISBN-13(EAN): 9781627034166
Издательство: Springer
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Цена: 32652.00 р.
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Описание: This book details current trends and state-of-the-art in cell and gene based therapies. Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies.

Liver-Directed Therapy for Primary and Metastatic Liver Tumors

Автор: Mark S. Talamonti; Sam G. Pappas
Название: Liver-Directed Therapy for Primary and Metastatic Liver Tumors
ISBN: 1475733739 ISBN-13(EAN): 9781475733730
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Liver-Directed Therapy for Primary and Metastatic Liver Tumors is a comprehensive examination of tumors of the liver. Because of the unique and comprehensive examination of liver tumors, this work is an excellent resource for surgical, transplant and medical oncologists, surgeons, gastroenterologists, and radiologists.

Gene Delivery and Therapy for Neurological Disorders

Автор: Xuenong Bo; Joost Verhaagen
Название: Gene Delivery and Therapy for Neurological Disorders
ISBN: 1493923056 ISBN-13(EAN): 9781493923052
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors` laboratories.

Viral Vectors for Gene Therapy

Автор: Otto-Wilhelm Merten; Mohamed Al-Rubeai
Название: Viral Vectors for Gene Therapy
ISBN: 1493958283 ISBN-13(EAN): 9781493958283
Издательство: Springer
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Цена: 16769.00 р.
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Описание: The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Gene Therapy for Neurological Disorders

Автор: Fredric P. Manfredsson
Название: Gene Therapy for Neurological Disorders
ISBN: 1493948962 ISBN-13(EAN): 9781493948963
Издательство: Springer
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Цена: 19564.00 р.
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Описание:

Part I Introduction

1. Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System
Frederic P. Manfredsson

Part II Expression Cassettes

2. Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors
Matthew L. Hirsch, Sonya J. Wolfe, and R. J. Samulski

3. Expression of Multiple Functional RNAs or Proteins from One Viral Vector
Tomas Bjцrklund

4. Regulated Gene Therapy
Ludivine Breger, Erika Elgstrand Wettergren, Luis Quintino, and Cecilia Lundberg

5. Design of shRNA and miRNA for Delivery to the CNS
Gabriela Toro and Christian Mueller

6. Tissue Specific Promoters in the CNS
Sebastian Kьgler

Part III Viral Vector Production

7. Small Scale Recombinant Adeno-Associated Virus Purification
Corinna Burger and Kevin Nash

8. Lentivirus Production and Purification
Matthew J. Benskey and Frederic P. Manfredsson

9. Viral Vector Production: Adenovirus
Julius W. Kim, Ramin A. Morshed, J. Robert Kane, Brenda Auffinger, Jian Qiao, and Maciej S. Lesniak

Part IV Viral Vector Tropism

10. Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids
Michael J. Castle, Heikki T. Turunen, Luk H. Vandenberghe, and John H. Wolfe

11. Altering Tropism of rAAV by Directed Evolution
Damien Marsic and Sergei Zolotukhin

12. Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins
Kenta Kobayashi, Shigeki Kato, Ken0ichi Inoue, Masahiko Takada, and Kazuto Kobayashi

13. Directed Evolution of Adenoviruses
Jason G. Smith

Part V Delivery Methods

14. Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling
Matthew J. Benskey and Frederic P. Manfredsson

15. MRI-Guided Delivery of Viral Vectors
Ernesto A. Salegio, John Bringas, Krystof S. Bankiewicz

16. Systemic Gene Therapy for Targeting the CNS
Sara E. Gombash and Kevin D. Foust

17. Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection
Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky

18. AAV-Mediated Gene Transfer to Dorsal Root Ganglion
Hongwei Yu, Gregory Fischer, and Quinn H. Hogan

19. Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System
Matthew J. Benskey and Frederic P. Manfredsson

20. Gene Therapy of the Peripheral Nervous System: Celiac Ganglia

21. Convection Enhanced Delivery of Recombinant Adeno-Associated Virus into the Mouse Brain
Kevin R. Nash and Marcia N. Gordon

22. Non-Viral Gene Therapy of the Nervous System: Electroporation
XueFeng Ding and Ming Fan

23. Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection
James G. Hecker

24. Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model
Masatoshi Suzuki and Clive N. Svendsen

Part VI Gene-Therapy Based Modeling of Neurodegenerative Disorders

25. Gene Therapy Models of Alzheimer's Disease and Other Dementias
Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan

26. Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease
D. Luke Fischer, Sara E. Gombash, Christopher J. Kemp, Frederic P. Manfredsson, Nicole K. Polinski, Megan F. Duffy, and Caryl E. Sortwell

27. Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease
Deborah Young

Part VII Gene-Therapy for the Treatment of Neurological Disorders

28. Gen


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