Описание: This book describes analytical methods used to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. It details these methods in both in vitro and non-invasive in vivo methodologies.
Автор: Bruno Filipe Carmelino Ca Название: Concepts and models for drug permeability studies ISBN: 0081000944 ISBN-13(EAN): 9780081000946 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.
Автор: Huang Название: Case Studies in Modern Drug Discovery and Development ISBN: 0470601817 ISBN-13(EAN): 9780470601815 Издательство: Wiley Рейтинг: Цена: 19792.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Using case studies of successful drug discoveries and launches, this book helps master the necessary knowledge of the drug discovery process. It includes pharmacology, drug metabolism, biology, drug development, and clinical studies.
Автор: Ronald T. Borchardt; Philip L. Smith; Glynn Wilson Название: Models for Assessing Drug Absorption and Metabolism ISBN: 1489918655 ISBN-13(EAN): 9781489918659 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems.
Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso Название: Predictive Methods in Percutaneous Absorption ISBN: 3662508311 ISBN-13(EAN): 9783662508312 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation.
Описание: This book describes analytical methods used to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. It details these methods in both in vitro and non-invasive in vivo methodologies.
Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso Название: Predictive Methods in Percutaneous Absorption ISBN: 3662473704 ISBN-13(EAN): 9783662473702 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Автор: N.R. Cutler; P.K. Narang Название: Drug Studies in the Elderly ISBN: 1468412558 ISBN-13(EAN): 9781468412550 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Clinical trials are the most definitive tool for evaluation of the applica- bility of clinical investigations. Because of an ever-increasing elderly population, newer policies for clinical investigations are now being debated with the recognition of enhanced drug sensitivity in this special population.
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