Xin Zhang Multistate GTPase Control Co-translational Protein Targeting 9781489978080

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Автор: Xin Zhang
Название: Multistate GTPase Control Co-translational Protein Targeting
ISBN: 9781489978080
Издательство: Springer
Классификация:

Аналитическая химия

Биохимия

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ISBN-10: 1489978089
Обложка/Формат: Paperback
Страницы: 96
Вес: 0.16 кг.
Дата издания: 23.08.2016
Серия: Springer Theses
Язык: English
Издание: Softcover reprint of
Иллюстрации: 2 tables, black and white; vii, 96 p.; 2 tables, black and white; vii, 96 p.
Размер: 234 x 156 x 6
Читательская аудитория: General (us: trade)
Основная тема: Chemistry
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes. Written while completing graduate work at California Institute of Technology.
Дополнительное описание: Introduction.- A Multistep Mechanism for Assembly of the SRP-SR Complex.- Dynamics of the Transient Intermediate during SRP-SR Association.- Multiple Conformational Switches Control Cotranslational Protein Targeting.- Sequential Checkpoints Govern Substra

Multistate GTPase Control Co-translational Protein Targeting, Xin Zhang