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Molecular Profiling, Virginia Espina; Lance A. Liotta
Virginia Espina; Lance A. Liotta Molecular Profiling 9781493956845

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Автор: Virginia Espina; Lance A. Liotta
Название:  Molecular Profiling
ISBN: 9781493956845
Издательство: Springer
Классификация:
Медицинское оборудования и методики его эксплуатации

Медицинские исследования

Патологическая анатомия / Клиническая лабораторная диагностика

ISBN-10: 1493956841
Обложка/Формат: Paperback
Страницы: 447
Вес: 0.88 кг.
Дата издания: 23.08.2016
Серия: Methods in Molecular Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 19 tables, black and white; xiii, 447 p.
Размер: 254 x 178 x 24
Читательская аудитория: General (us: trade)
Основная тема: Biomedicine
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание:

Contents

Preface

Contributors

1. Tumor Staging and Grading: A Primer

Stacy M. Cowherd

2. Clinical Trial Design in the Age of Molecular Profiling

Alexander Spira and Kirsten H. Edmiston

3. Personalized Medicine: Ethics for Clinical Trials

G. Terry Sharrer

4. Reduction of Preanalytical Variability in Specimen Procurement for Molecular Profiling

Virginia Espina and Claudius Mueller

5. The Human Side of Cancer Biobanking

Eoin Gaffney, Deirdre Madden, and Geraldine A. Thomas

6. Introduction to Genomics

Luca Del Giacco and Cristina Cattaneo

7. Genomic Profiling: cDNA arrays and oligoarrays

Francesco Gorreta, Walter Carbone, Dagania Barzhagi

8. Genome wide methylation profiling in archival formalin fixed paraffin embedded (FFPE) tissue samples

J. Keith Killian, Robert L. Walker, Sven Bilke, Yidong Chen, Sean Davis, Robert Cornelison, William I. Smith, and Paul S. Meltzer

9. An Overview of microRNA Methods: Expression Profiling and Target Identification

Sinйad M Smith and David W Murray

10. Antibody Validation by Western Blotting

Michele Signore and K. Alex Reeder

11. Laser Capture Microdissection: ArcturusXT infra-red capture and UV cutting methods

Rosa I. Gallagher, Steven R. Blakely, Lance A. Liotta, and Virginia Espina

12. Antibody microarrays: Analysis of Cystic Fibrosis

Catherine E. Jozwik, Harvey B. Pollard, Meera Srivastava, Ofer Eidelman, QingYuan Fan, Thomas N. Darling, and Pamela L. Zeitlin

13. Tissue Microarrays As A Tool In The Discovery & Validation Of Predictive Biomarkers

Stephen M. Hewitt

14. Reverse phase protein microarrays

Mariaelena Pierobon, Francesca Galdi, Noemi Moroni, and Emanuel F. Petricoin III

15. Serum Low Molecular Weight Protein Fractionation for Biomarker Discovery

Amy VanMeter, Serena Camerini, Maria Letizia Polci, Alessandra Tessitore, Nishant Trivedi, Michael Heiby, Jonathan Hansen, and Weidong Zhou

16. Mass spectrometry based biomarker discovery

Weidong Zhou, Emanuel F. Petricoin III, and Caterina Longo

17. Mitochondrial Proteome: Toward The Detection and Profiling of Disease Associated Alterations

Paul C. Herrmann and E. Clifford Herrmann

18. Adult Neural Stem Cells: Isolation and Propagation

Jamin M. Lechter and Daniel N. Cox

19. Evanescent Wave Imaging: An Introduction to Total Internal Reflection Fluorescence Microscopy (TIRF)

Bryan A. Millis

20. Construction and Hyperspectral Imaging of Quantum Dot Lysate Arrays

Kevin P. Rosenblatt, Michael Huebschman, and Harold R. Garner

21. Microarray Data Analysis: Comparing Two Population Means

Jianghong Deng, Valerie S. Calvert and Mariaelena Pierobon

22. Bioinformatics/Biostatistics: microarray analysis

Gabriel S. Eichler

23. Structure-based functional design of drugs: from target to lead compound

Amy C. Anderson

24. Personalized Medicine: Changing the Paradigm of Drug Development

Robin Couch and Bryan T. Mott

25. Grant Writing Tips for the First Time Applicant

Lindsay Wescott and Michael Laskofski

26. Inventions and Patents: A practical tutorial

J. Lille Tidwell and Lance Liotta

27. Regulatory Approval Pathways for Molecular Diagnostic Technology

Lance Liotta and Emanuel Petricoin

28. Small business development for molecular diagnostics

Athanasia Anagnostou and Lance Liotta


Дополнительное описание: Tumor Staging and Grading: A Primer.-Clinical Trial Design in the Age of Molecular Profiling.-Personalized Medicine: Ethics for Clinical Trials.-Reduction of Preanalytical Variability in Specimen Procurement for Molecular Profiling.-The Human Side of Canc



Molecular Profiling

Автор: Virginia Espina
Название: Molecular Profiling
ISBN: 1493969897 ISBN-13(EAN): 9781493969890
Издательство: Springer
Рейтинг:
Цена: 20962.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

1. Tumor Staging and Grading: A Primer

Stacy M. Telloni

2. Innovations in Clinical Trial Design in the Era of Molecular Profiling

Julia D. Wulfkuhle, Alexander Spira, Kirsten H. Edmiston, and Emanuel F. Petricoin

3. Personalized Medicine: Ethical Aspects

G. Terry Sharrer

4. Antibody Validation by Western Blotting

Michele Signore, Valeria Manganelli and Alex Hodge

5. Scanning Electron Microscopy Sample Preparation and Imaging

Jenny Ngoc Tran Nguyen and Amanda M. Harbison

Claudius Mueller, Michael G. Harpole, and Virginia Espina

7. Application of Hydrogel Nanoparticles for the Capture, Concentration, and Preservation of Low-Abundance Biomarkers

Ruben Magni and Alessandra Luchini

8. Using Laser Capture Microdissection to Isolate Cortical Laminae in Non-human Primate Brain

Brian A. Corgiat and Claudius Mueller

9. Western Blot Techniques

Brianna Kim

10. ELISA for Monitoring Nerve Growth Factor

Justin B. Davis

11. Reverse Phase Protein Microarrays

Elisa Baldelli, Valerie Calvert, Alex Hodge, Amy VanMeter, Emanuel F. Petricoin III, and Mariaelena Pierobon

12. Clustering and Network Analysis of Reverse-Phase Protein Array Data

Adam Byron

13. PCR: Identification of Genetic Polymorphisms

Amanda M. Harbison and Jenny Ngoc Tran Nguyen

14. Microsatellite Analysis for Identification of Individuals Using Bone from the Extinct Steller's Sea Cow (Hydrodamalis gigas)

Jeffery F. Warner, Michael G. Harpole, and Lorelei D. Crerar

15. Somatic DNA Mutation Analysis

Anthony O'Grady and Robert Cummins

16. Optimization of Immunostaining for Prospective Image Analysis

Scott M. Lawrence and Yelena G. Golubeva

17. Fluorescence in situ Hybridization of Cells, Chromosomes, and Formalin Fixed Paraffin Embedded Tissues

Ahmad Alamri, Jun Yeb Nam, and Jan K. Blancato

18. High-Resolution Image Stitching as a Tool to Assess Tissue-Level Protein Distribution and Localization

Bryan A. Millis and Matthew J. Tyska

19. Mass Spectrometry Based Biomarker Discovery

Weidong Zhou, Emanuel F. Petricoin III, and Caterina Longo

20. Quantitative Mass Spectrometry by Isotope-Dilution and Multiple Reaction Monitoring (MRM)

Paul Russo, Brian L. Hood, Nicholas W. Bateman, Thomas P. Conrads

21. LC-Mass Spectrometry for Metabolomics Allyson L. Dailey

22. Metabolomic Bioinformatic Analysis

Allyson L. Dailey

23. Stable Isotope Quantitative N-glycan Analysis by Liquid Separation Techniques and Mass Spectrometry

Stefan Mittermayr, Simone Albrecht, Csaba Vбradi, Silvia Millбn-Martнn, and Jonathan Bones

24. Grant Writing Tips for Translational Research

Lindsay Wescott, Michael Laskofski, Donna Senator, and Carly Curran

25. Inventions and Patents: A Practical Tutorial

Hina Mehta, Lille Tidwell, and Lance A. Liotta

26. Product Development and Commercialization of Diagnostic or Life Science Products for Scientists and Researchers

Meghan M. Alonso
Cellular Cardiomyoplasty: Methods and Protocols (Methods in Molecular Biology)

Автор: Race L. Kao (Editor)
Название: Cellular Cardiomyoplasty: Methods and Protocols (Methods in Molecular Biology)
ISBN: 1627035109 ISBN-13(EAN): 9781627035101
Издательство: Springer
Рейтинг:
Цена: 16769.00 р.
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Описание: In Cellular Cardiomyoplasty: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study cellular cardiomyoplasty, only adult stem cells or adult progenitor cells are included.

Candida albicans: Cellular and Molecular Biology

Автор: Rajendra Prasad
Название: Candida albicans: Cellular and Molecular Biology
ISBN: 3319504088 ISBN-13(EAN): 9783319504087
Издательство: Springer
Рейтинг:
Цена: 27950.00 р.
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Описание: 1. Fungal infectionsJohn E Edwards1 and Priya Uppuluri2UCLA David Geffen School of Medicine, USA. 1E-mail: jedwards@labiomed.org, 2E-mail: puppuluri@labiomed.org2. Fungal infections- The South-Asian perspectiveArunaloke ChakrabartiDivision of Mycology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. E-mail: arunaloke@gmail.com3. Regulatory pathways during C. albicans infectionsAaron P. MitchellMellon Institute, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, USA. E-mail: apm1@andrew.cmu.edu4. Virulence mechanisms and regulationChristophe D'EnfertFungal Biology and Pathogenicity Unit - INRA USC2019, Department of Mycology, Institut Pasteur, Paris, France. E-mail: christophe.denfert@pasteur.fr
5. Signalling mechanisms in pathogenesis and virulence of C. albicans 6. Biofilm development by C. albicansDavid AndesDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison WI, USA. E-mail: dra@medicine.wisc.edu7. Biofilm development and resistance mechanisms by C. albicansPatrick Van Dijck1 and Mary-Ann Jabra Rizk21 VIB Department of Molecular Microbiology, KU Leuven, Kasteelpark, Arenberg, Leuven, Belgium. 2 University of Maryland School of Dentistry, Maryland, USA. 1E-mail: Patrick.VanDijck@mmbio.vib-kuleuven.be, 2E-mail: MRizk@umaryland.edu8. Biofilm of C. albicans: development and regulationAshraf S. Ibrahim1 and Priya Uppuluri29. Host immune responses during infectionsGordon BrownThe Institute of Medical Sciences, University of Aberdeen, Scotland. E-mail: gordon.brown@abdn.ac.uk10. Mechanism of drug resistance Dominique SanglardInstitute of Microbiology, University Hospital Lausanne and University Hospital Center, Lausanne, Switzerland. E-mail: Dominique.Sanglard@chuv.ch11. Structure- function analyses of Multi-drug transportersRichard D. Cannon Department of Oral Sciences, University of Otago, Dunedin, New Zealand. E-mail: richard.cannon@otago.ac.nz12. All about MFS multi-drug transporter of Candida albicansRajendra Prasad1, Peer Abdul Haseeb Shah2 and Archana Redhu21Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University, Haryana, India. 2Membrane biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. 1E-mail: rp47jnu@gmail.com, rprasad@ggn.amity.edu13. Inhibitors/Modulators of MDR transporters Attilio Di PietroInstitute for the Biology and Chemistry of Protein, Lyon, France. E-mail: a.dipietro@ibcp.fr14. Inhibitors/Modulators of MDR proteins/transportersBrian MonkDepartment of Oral Sciences, University of Otago, Dunedin, New Zealand. E-mail: brian.monk@otago.ac.nz15. Anti-fungals
David PerlinPublic Health Research Institute Center, New Jersey Medical School - Rutgers, The State University of New Jersey, New Jersey, USA. E-mail: perlinds@umdnj.edu16. Anti-microbial peptidesJoachim Ernst and Marc SwidergallInstitut fьr Mikrobiologie, Molekulare M

Molecular Pathology

Автор: Coleman, William
Название: Molecular Pathology
ISBN: 0128027614 ISBN-13(EAN): 9780128027615
Издательство: Elsevier Science
Рейтинг:
Цена: 19875.00 р.
Наличие на складе: Поставка под заказ.

Описание:

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.

The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

  • Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease
  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology
  • Teaches from the perspective of "integrative systems biology"
  • Enhanced digital version included with purchase
Precision Molecular Pathology of Myeloid Neoplasms

Автор: Chung-Che (Jeff) Chang; Robert S. Ohgami
Название: Precision Molecular Pathology of Myeloid Neoplasms
ISBN: 3319621440 ISBN-13(EAN): 9783319621449
Издательство: Springer
Рейтинг:
Цена: 27950.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.

Cell Aging: Molecular Mechanisms and Implications for Disease

Автор: Christian Behl; Christine Ziegler
Название: Cell Aging: Molecular Mechanisms and Implications for Disease
ISBN: 3642451780 ISBN-13(EAN): 9783642451782
Издательство: Springer
Рейтинг:
Цена: 9141.00 р.
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Описание: Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors.

Molecular Structures and Structural Dynamics of Prion Proteins and Prions

Автор: Jiapu Zhang
Название: Molecular Structures and Structural Dynamics of Prion Proteins and Prions
ISBN: 9401773173 ISBN-13(EAN): 9789401773171
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in ?-helices but PrPSc are rich in ?-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

Molecular Therapies of Cancer

Автор: Georg F. Weber
Название: Molecular Therapies of Cancer
ISBN: 3319132776 ISBN-13(EAN): 9783319132778
Издательство: Springer
Рейтинг:
Цена: 25155.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.


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