Ubiquitin Family Modifiers and the Proteasome, R. J?rgen Dohmen; Martin Scheffner
Автор: M. Rechsteiner Название: Ubiquitin ISBN: 148992051X ISBN-13(EAN): 9781489920515 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Cam Patterson; Douglas M. Cyr Название: Ubiquitin-Proteasome Protocols ISBN: 1617374539 ISBN-13(EAN): 9781617374531 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.
Описание: Martin Stein`s thesis describes a novel methodology for natural product discovery. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens.
Описание: Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.
Автор: Stefan Jentsch; Bernhard Haendler Название: The Ubiquitin System in Health and Disease ISBN: 3642098800 ISBN-13(EAN): 9783642098802 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. This book presents the developments in this field.
Автор: De, Arnab Название: Ubiquitin chains ISBN: 3319149644 ISBN-13(EAN): 9783319149646 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis examines the evidence for regulatory ubiquitination by focusing on A20.
Автор: Jan-Michael Peters; J. Robin Harris; Daniel Finley Название: Ubiquitin and the Biology of the Cell ISBN: 1489919244 ISBN-13(EAN): 9781489919243 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The last several years have been a landmark period in the ubiquitin field. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M.
Описание: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation.
Автор: Antonio Baici Название: Kinetics of Enzyme-Modifier Interactions ISBN: 3709114012 ISBN-13(EAN): 9783709114018 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Автор: Duncan E.S. Stewart-Tull; Max Sussman Название: The Release of Genetically Modified Microorganisms—REGEM 2 ISBN: 1461276543 ISBN-13(EAN): 9781461276548 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a symposium held under the auspices of the Federation of European Microbiological Societies, in Nottingham, England, August 29-31, 1991.
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