Ubiquitin-Proteasome Protocols, Cam Patterson; Douglas M. Cyr

Автор: Stefan Jentsch; Bernhard Haendler
Название: The Ubiquitin System in Health and Disease
ISBN: 3642098800 ISBN-13(EAN): 9783642098802
Издательство: Springer
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Описание: The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. This book presents the developments in this field.

Автор: De, Arnab
Название: Ubiquitin chains
ISBN: 3319149644 ISBN-13(EAN): 9783319149646
Издательство: Springer
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Описание: This thesis examines the evidence for regulatory ubiquitination by focusing on A20.

Автор: Martin Lorenz Stein
Название: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens
ISBN: 3319079131 ISBN-13(EAN): 9783319079134
Издательство: Springer
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Описание: Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.

Автор: Jan-Michael Peters; J. Robin Harris; Daniel Finley
Название: Ubiquitin and the Biology of the Cell
ISBN: 1489919244 ISBN-13(EAN): 9781489919243
Издательство: Springer
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Описание: The last several years have been a landmark period in the ubiquitin field. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M.

Автор: M. Rechsteiner
Название: Ubiquitin
ISBN: 148992051X ISBN-13(EAN): 9781489920515
Издательство: Springer
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Автор: R. J?rgen Dohmen; Martin Scheffner
Название: Ubiquitin Family Modifiers and the Proteasome
ISBN: 1493959050 ISBN-13(EAN): 9781493959051
Издательство: Springer
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Цена: 23058.00 р.
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Описание: This volume presents novel developments in UPS research and important methods related to recent advances in the field. The volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, and more.

Автор: Martin Lorenz Stein
Название: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens
ISBN: 331938399X ISBN-13(EAN): 9783319383996
Издательство: Springer
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Цена: 13059.00 р.
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Описание: Martin Stein`s thesis describes a novel methodology for natural product discovery. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens.