Malaria, Robert M?nard

Автор: Henry M. Staines; Sanjeev Krishna
Название: Treatment and Prevention of Malaria
ISBN: 3034808089 ISBN-13(EAN): 9783034808088
Издательство: Springer
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Описание: Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.

Автор: David Sullivan; Sanjeev Krishna
Название: Malaria: Drugs, Disease and Post-genomic Biology
ISBN: 364206471X ISBN-13(EAN): 9783642064715
Издательство: Springer
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Описание: Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world`s best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.

Автор: Krishna R. Dronamraju; Paolo Arese
Название: Malaria
ISBN: 1441921028 ISBN-13(EAN): 9781441921024
Издательство: Springer
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Описание: This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called "Malaria Hypothesis", that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane's contribution from two directions: (a) it has been suggested that the "Malaria Hypothesis" was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane's malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.