Автор: Amanda L. Garner Название: RNA Therapeutics ISBN: 3319680900 ISBN-13(EAN): 9783319680903 Издательство: Springer Рейтинг: Цена: 39130.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Автор: Albrecht Bindereif Название: RNA Metabolism in Trypanosomes ISBN: 3642433251 ISBN-13(EAN): 9783642433252 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.
Автор: Patrick J. Paddison; Peter K. Vogt Название: RNA Interference ISBN: 3642444458 ISBN-13(EAN): 9783642444456 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and industry. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
Описание: This book covers the design and synthesis of DNA and RNA nanostructures with the aim of using them for drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, and siRNA delivery for cancer treatment.
Описание: Proceedings of the NATO Advanced Research Workshop on `DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases`, Toulouse, France, September 11-14, 1995
Автор: Dagmar Wilhelm; Pascal Bernard Название: Non-coding RNA and the Reproductive System ISBN: 9401774153 ISBN-13(EAN): 9789401774154 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.
Автор: Imre Gaspar Название: RNA Detection ISBN: 149397212X ISBN-13(EAN): 9781493972128 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume introduces different concepts and methods of detecting RNA in biological material in a variety of model systems.
Автор: Kenneth C. Keiler Название: Bacterial Regulatory RNA ISBN: 1493959417 ISBN-13(EAN): 9781493959419 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) volume covers methods and techniques to identify regulatory RNAs, characterizing the function and expression of regulatory RNAs in bacterial cells, RNA structure prediction and interaction between regulatory RNAs and proteins.
Автор: Daniel R. Perez Название: Reverse Genetics of RNA Viruses ISBN: 1493969625 ISBN-13(EAN): 9781493969623 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Reverse Genetics for Mammalian Orthoreovirus
Johnasha D. Stuart, Matthew B. Phillips, and Karl W. Boehme
2. Development and Characterization of an Infectious cDNA Clone of Equine Arteritis Virus
Udeni B. R. Balasuriya and Jianqiang Zhang
3. Reverse Genetics for Porcine Reproductive and Respiratory Syndrome Virus
Mingyuan Han, Hanzhong Ke, Yijun Du, Qingzhan Zhang, and Dongwan Yoo
4. Reverse Genetics of Zika Virus
Chao Shan, Xuping Xie, and Pei-Yong Shi
5. Efficient Reverse Genetic Systems for Rapid Genetic Manipulation of Emergent and
Pre-Emergent Infectious Coronaviruses
Adam S. Cockrell, Anne Beall, Boyd Yount, and Ralph Baric
6. Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis Virus
Erica Bickerton, Sarah M. Keep, and Paul Britton
7. Rescue of Sendai Virus from Cloned cDNA
Shringkhala Bajimaya, Tsuyoshi Hayashi, and Toru Takimoto
8. BAC-based Recovery of Recombinant Respiratory Syncytial Virus (RSV)
Christopher C. Stobart, Anne L. Hotard, Jia Meng, and Martin L. Moore
9. Recovery of a Paramyxovirus, the Human Metapneumovirus, from Cloned cDNA
B.G. van den Hoogen and R.A.M Fouchier
10. Reverse Genetics of Newcastle Disease Virus
Stivalis Cardenas-Garcia and Claudio L. Afonso
11. Reverse Genetics Systems for Filoviruses
Thomas Hoenen and Heinz Feldmann
12. Rapid Reverse Genetics Systems for Rhabdoviruses- From Forward to Reverse and Back Again
Tobias Nolden and Stefan Finke
13. Lassa Virus Reverse Genetics
Luis Martнnez-Sobrido, Slobodan Paessler, and Juan Carlos de la Torre
14. Reverse Genetics of Influenza B Viruses
Aitor Nogales, Daniel R. Perez, Jefferson Santos, Courtney Finch, and Luis Martнnez-Sobrido
15. Rescue of Infectious Salmon Anemia Virus (ISAV) from Cloned cDNA
Daniela Toro-Ascuy and Marcelo Cortez-San Martнn
16. Plasmid-based Reverse Genetics of Influenza a Virus
Daniel R. Perez, Matthew Angel, Ana Silvia Gonzalez-Reiche, Jefferson Santos, Adebimpe Obadan, and Luis Martinez Sobrido
Автор: Yeo Название: RNA Processing ISBN: 3319290711 ISBN-13(EAN): 9783319290713 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.
Автор: Jane Y. Wu Название: RNA and Cancer ISBN: 3642444857 ISBN-13(EAN): 9783642444852 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.
Автор: Graeme L. Conn Название: Recombinant and In Vitro RNA Synthesis ISBN: 1493958305 ISBN-13(EAN): 9781493958306 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part of Springer`s Methods in Molecular Biology series, this collection of detailed protocols guides the reader from the start of a new RNA project to the final sample, with step-by-step protocols and expert tips on deploying catalytic RNAs in the laboratory.
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