Автор: Juan C. Stockert; Jes?s Espada; Alfonso Bl?zquez-C Название: Functional Analysis of DNA and Chromatin ISBN: 1627037055 ISBN-13(EAN): 9781627037051 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Covering standard and recently developed methods in functional analysis of genetic material, this new volume in the Methods in Molecular Biology series includes reproducible protocols, expert problem-solving tips, and improved techniques for histone analysis.
Автор: Jerry L. Workman; Susan M. Abmayr Название: Fundamentals of Chromatin ISBN: 1493945262 ISBN-13(EAN): 9781493945269 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on fundamental properties of chromatin that include structure, composition, modifications and functions in nuclear processes such as transcription, and DNA replication and repair.
Автор: Gondor, Anita Название: Chromatin Regulation and Dynamics ISBN: 0128033959 ISBN-13(EAN): 9780128033951 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
Chromatin Regulation and Dynamics" integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.
Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, "Chromatin Regulation and Dynamics," part of the "Translational Epigenetics" series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspectivePromotes crosstalk between basic sciences and their applications in medicineProvides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principlesIntegrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Автор: Juan C. Stockert; Jes?s Espada; Alfonso Bl?zquez-C Название: Functional Analysis of DNA and Chromatin ISBN: 1493960482 ISBN-13(EAN): 9781493960484 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Covering standard and recently developed methods in functional analysis of genetic material, this new volume in the Methods in Molecular Biology series includes reproducible protocols, expert problem-solving tips, and improved techniques for histone analysis.
Автор: Andrew Emili; Jack Greenblatt; Shoshana Wodak Название: Systems Analysis of Chromatin-Related Protein Complexes in Cancer ISBN: 1493900897 ISBN-13(EAN): 9781493900893 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book identifies RNA molecules associated with various chromatin-modifying machines. It explores the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells).
Автор: Andrew Emili; Jack Greenblatt; Shoshana Wodak Название: Systems Analysis of Chromatin-Related Protein Complexes in Cancer ISBN: 1461479304 ISBN-13(EAN): 9781461479307 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book identifies RNA molecules associated with various chromatin-modifying machines. It explores the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells).
Автор: Jerry L. Workman Название: Protein Complexes that Modify Chromatin ISBN: 3642629091 ISBN-13(EAN): 9783642629099 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome.
Автор: Binda, Olivier Название: Chromatin Signaling and Diseases ISBN: 0128023899 ISBN-13(EAN): 9780128023891 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
Chromatin Signaling" "and Diseases" covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.
Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in "Chromatin Signaling and Diseases." Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with agingEducates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathologyExplores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signalingHelps researchers learn about the quickly expanding field of chromatin signaling
Название: Fundamentals of Chromatin ISBN: 1461486238 ISBN-13(EAN): 9781461486237 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on fundamental properties of chromatin that include structure, composition, modifications and functions in nuclear processes such as transcription, and DNA replication and repair.
Автор: Srikumar P. Chellappan Название: Chromatin Protocols ISBN: 1493956264 ISBN-13(EAN): 9781493956265 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Significant advancements have been made in the study of chromatin structure and function over the past fifty years but none as spectacular as those made in the last decade due to the development of novel techniques and the ability to sequence large stretches of DNA. In Chromatin Protocols, Second Edition, expert researchers delineate these cutting-edge techniques via step-by-step laboratory methods and protocols, which encompass a wide array of topics from the isolation of nucleosomes, assembly of nucleosomes and study of the basic chromatin structure to detailed analysis of histone modifications and chromatin function. Written in the highly successful Methods in Molecular Biology™ series style, chapters include brief introductions to the subjects, lists of the necessary materials and reagents, readily reproducible protocols, and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Chromatin Protocols, Second Edition is a valuable tool for scientists studying various aspects of chromatin function and an ideal guide to aid in the development of new techniques as well as new ideas in the field of chromatin biology.
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