Skeletal Development and Repair, Matthew J. Hilton

Автор: Nigel G. Laing
Название: The Sarcomere and Skeletal Muscle Disease
ISBN: 1441927417 ISBN-13(EAN): 9781441927415
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This book reviews diseases caused by mutated proteins in the different sub-compartments of the sarcomere. It also documents techniques used to investigate the pathobiological bases of the diseases and discusses possible therapeutic options.

Автор: Eva Za??malov?; Jan Petr??ek; Eva Benkov?
Название: Auxin and Its Role in Plant Development
ISBN: 3709119693 ISBN-13(EAN): 9783709119693
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book offers comprehensive, detailed insight into the hormone auxin, covering the function, metabolism and signaling pathways of auxin in plants, the role of auxin in plant development and interaction and function of auxin on stimuli of the environment.

Автор: James G. Ryall
Название: Skeletal Muscle Development
ISBN: 1493972820 ISBN-13(EAN): 9781493972821
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This detailed volume presents a wide range of techniques that go beyond the standard assays typically used to assess Myogenesis. The content included addresses assays to analyze skeletal muscle gene expression, proliferating muscle cells, the process of myoblast fusion, muscle development (in vivo), as well as muscle repair.

Автор: Stefano Schiaffino; Terence Partridge
Название: Skeletal Muscle Repair and Regeneration
ISBN: 9048177189 ISBN-13(EAN): 9789048177189
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles.

Автор: Elizabeth A. DiGangi
Название: Research Methods in Human Skeletal Biology,
ISBN: 0123851890 ISBN-13(EAN): 9780123851895
Издательство: Elsevier Science
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Цена: 12462.00 р.
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Описание: Showing you how to conduct research in general, this title also reveals how research is specifically conducted within human skeletal biology. It outlines the advanced types of research being conducted within each sub-specialty of skeletal biology, and gives the reader the tools to set up a research project in skeletal biology.

Автор: Jennifer C. Love; Sharon M. Derrick; Jason M. Wier
Название: Skeletal Atlas of Child Abuse
ISBN: 1493958569 ISBN-13(EAN): 9781493958566
Издательство: Springer
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Цена: 23058.00 р.
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Описание: This illustrated guide to the role of the forensic anthropologist in investigating child abuse is an essential resource in one of the most contentious areas of forensic pathology. Not only does it supply a review of the literature in this field, but it illustrates the material with photographs from real cases investigated by the Harris County Institute of Forensic Sciences, which serves a population of four million people. Broken down into body regions and skeletal elements for ease of reference, the atlas facilitates the vital work performed by forensic anthropologists, who bring to the autopsy table a store of specialist knowledge that can turn a case. Despite the frequency of child fatalities (in America, 2.3per 100,000) attributed to physical abuse, merely recognizing the offense is a major forensic challenge. The tell-tale signatures of non-accidental injury can be very subtle, making it difficult to differentiate between accidental and non-accidental injury. Yet successful adjudication of a child abuse case often rests on the correct interpretation of skeletal injury. In this volume the authors guide the reader through published data regarding the mechanics and interpretation of injuries,including the agencies they indicate. The material includes discussion of the limitations faced in interpreting some injuries, where making a judgment on cause is tricky. In addition, a chapter on natural diseases affecting the bones provides a good overview of several conditions that are often invoked as 'mimics' of child abuse. Finally, this publication evinces the value of collaboration between the pathologist and the anthropologist.

Автор: S.R. Hilfer; J.B. Sheffield
Название: Ocular Size and Shape Regulation During Development
ISBN: 1461259665 ISBN-13(EAN): 9781461259664
Издательство: Springer
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Цена: 14365.00 р.
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Описание: Based on Papers Presented at the 5th Symposium on Ocular and Visual Development, Philadelphia, June 1980

Автор: Alexander von Gabain; Christoph Klade
Название: Development of Novel Vaccines
ISBN: 3709117046 ISBN-13(EAN): 9783709117040
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Covering the entire process of developing a vaccine-from early, basic research right up to the final product itself, and approaching the subject from a variety of perspectives, this volume will be required reading for researchers engaged in vaccine creation.

Автор: Erik Mosekilde; Olga Sosnovtseva; Amin Rostami-Hod
Название: Biosimulation in Biomedical Research, Health Care and Drug Development
ISBN: 370911764X ISBN-13(EAN): 9783709117644
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Biosimulation is a medical research and treatment approach that employs computer modeling alongside experimental and clinical work. The book explains the concepts used in modeling biological phenomena and goes on to present a series of well-documented models.

Автор: Mohammad Anwar Hossain; Mohammad Golam Mostofa; Pe
Название: Glutathione in Plant Growth, Development, and Stress Tolerance
ISBN: 3319666819 ISBN-13(EAN): 9783319666815
Издательство: Springer
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Цена: 23757.00 р.
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Описание:

Glutathione (γ-glutamyl-cysteinyl-glycine) is a ubiquitously distributed sulfurcontaining antioxidant molecule that plays key roles in the regulation of plant growth, development, and abiotic and biotic stress tolerance. It is one of the most powerful low-molecular-weight thiols, which rapidly accumulates in plant cells under stress. Recent in-depth studies on glutathione homeostasis (biosynthesis, degradation, compartmentalization, transport, and redox turnover) and the roles of glutathione in cell proliferation and environmental stress tolerance have provided new insights for plant biologists to conduct research aimed at deciphering the mechanisms associated with glutathione-mediated plant growth and stress responses, as well as to develop stress-tolerant crop plants. Glutathione has also been suggested to be a potential regulator of epigenetic modifications, playing important roles in the regulation of genes involved in the responses of plants to changing environments. The dynamic relationship between reduced glutathione (GSH) and reactive oxygen species (ROS) has been well documented, and glutathione has been shown to participate in several cell signaling and metabolic processes, involving the synthesis of protein, the transport of amino acids, DNA repair, the control of cell division, and programmed cell death. Two genes, gamma-glutamylcysteine synthetase (GSH1) and glutathione synthetase (GSH2), are involved in GSH synthesis, and genetic manipulation of these genes can modulate cellular glutathione levels. Any fluctuations in cellular GSH and oxidized glutathione (GSSG) levels have profound effects on plant growth and development, as glutathione is associated with the regulation of the cell cycle, redox signaling, enzymatic activities, defense gene expression, systemic acquired resistance, xenobiotic detoxification, and biological nitrogen fixation. Being a major constituent of the glyoxalase system and ascorbate-glutathione cycle, GSH helps to control multiple abiotic and biotic stress signaling pathways through the regulation of ROS and methylglyoxal (MG) levels. In addition, glutathione metabolism has the potential to be genetically or biochemically manipulated to develop stress-tolerant and nutritionally improved crop plants. Although significant progress has been made in investigating the multiple roles of glutathione in abiotic and biotic stress tolerance, many aspects of glutathione-mediated stress responses require additional research.

The main objective of this volume is to explore the diverse roles of glutathione in plants by providing basic, comprehensive, and in-depth molecular information for advanced students, scholars, teachers, and scientists interested in or already engaged in research that involves glutathione. Finally, this book will be a valuable resource for future glutathione-related research and can be considered as a textbook for graduate students and as a reference book for frontline researchers working on glutathione metabolism in relation to plant growth, development, stress responses, and stress tolerance.

Автор: Hadjantonakis, Kat
Название: Cell Fate in Mammalian Development
ISBN: 0128042524 ISBN-13(EAN): 9780128042526
Издательство: Elsevier Science
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Цена: 21559.00 р.
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Описание:

Cell Fate in Mammalian Development, Volume 128, the latest release in the Current Topics in Developmental Biology series, provides reviews on cell fate in mammalian development. Each chapter is written by an international board of authors, with this release including sections on the Specification of extra-embryonic lineages during mouse pre-implantation development, Cell polarity and fate specification, The circuitry that drives trophectoderm identity, Breaking symmetry and the dynamics of transcription factors directing cell fate specification, Mechanics and cell fate, How physical properties of cells change in development and their effect on cell fate decisions, and more.

Автор: Kyba
Название: Skeletal Muscle Regeneration in the Mouse
ISBN: 1493938088 ISBN-13(EAN): 9781493938087
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume focuseson the cell biology and physiology of skeletal muscle regeneration. This Bookis a collection of classic and cutting edge protocols optimized for mice, butin most cases adaptable to rat or other mammalian models, that will allow aninvestigator to develop and implement a research study on skeletal muscleregeneration. Chapters address the three major areas of study: provoking regeneration by inducing damage to muscle, analyzing theprogenitor cells of skeletal muscle, and quantifying overall muscle function. Subjects discussed include: inducing skeletal muscle injury byeccentric contraction; volumetric muscle loss; single myofiber isolation andculture; satellite cell transplantation; muscle clearing for whole mountimmunostaining; luciferase tracking of muscle stem cells; mitochondrialand mitophagy flux analysis; in vivo assessment of muscle contractility;force measurements on single isolated myofibers; and analysis of aerobicrespiration in intact skeletal muscle tissue by microplate respirometry. Written in the highlysuccessful Methods in Molecular Biology series format,chapters include introductions to each respective topic, lists of the necessarymaterials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Cutting edge andpractical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory reference for research inskeletal muscle growth, damage, repair, degeneration, and regenerative therapyin the mouse model system.