mTOR Inhibition for Cancer Therapy: Past, Present and Future, Monica Mita; Alain Mita; Eric K. Rowinsky

Автор: R?diger Liersch; Wolfgang E. Berdel; Torsten Kessl
Название: Angiogenesis Inhibition
ISBN: 354078280X ISBN-13(EAN): 9783540782803
Издательство: Springer
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Цена: 27951.00 р.
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Описание: All aspects from the bench to the bedside are considered in this examination of the latest developments in angiogenesis inhibition in cancer. The authors pay detailed attention both to basic research and to its applications in clinical practice.

Автор: Marc Daeron; Eric Vivier
Название: Immunoreceptor Tyrosine-based Inhibition Motifs
ISBN: 3642636349 ISBN-13(EAN): 9783642636349
Издательство: Springer
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Цена: 15672.00 р.
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Описание: Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation.

Автор: R?diger Liersch; Wolfgang E. Berdel; Torsten Kessl
Название: Angiogenesis Inhibition
ISBN: 3642261434 ISBN-13(EAN): 9783642261435
Издательство: Springer
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Цена: 27951.00 р.
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Описание: All aspects from the bench to the bedside are considered in this examination of the latest developments in angiogenesis inhibition in cancer. The authors pay detailed attention both to basic research and to its applications in clinical practice.

Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).

Автор: Dey
Название: PI3K-mTOR in Cancer and Cancer Therapy
ISBN: 3319342096 ISBN-13(EAN): 9783319342092
Издательство: Springer
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Цена: 23508.00 р.
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Описание: In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway’s involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.?