Dissecting Regulatory Interactions of RNA and Protein, Marvin Jens
Автор: Marvin Jens Название: Dissecting Regulatory Interactions of RNA and Protein ISBN: 3319070819 ISBN-13(EAN): 9783319070810 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
Описание: The Human Brain in Dissection will significantly update the previous edition published in 1988. The last 20 years have sen a significant shift in the way that neuroanatomy is taught in both undergraduate and graduate neuroscience courses, as well as doctorate courses: not only has the time allocated for these courses been reduced, but the methodologies for teaching have become more focused and specific due to these time constraints. The Human Brain in Dissection, Third Edition will provide detailed features of the human brain with the above limitations in mind. 50 new plates will be added to the existing 123 in order to permit the student to see all salient structures and to visualize microscopic structures of the brain stem and spinal cord. Each chapter will cover a specific are of the human brain in such a way that each chapter can be taught in one two-hour neuroanatomy course. New to this edition is the inclusion of a section in each chapter on clinically relevant examples. Each chapter will also include a specific laboratory exercise. And finally, the author has included a question and answer section that is relevant to the USMLE, as as recommended readings, neither of which were included in the previous editions. This new edition of The Human Brain in Dissection will allow the student to: understand basic principles of cellular neuroscience; learn gross and microscopic anatomy of the central nervous system (Brain, brainstem, and spinal cord); relate the anatomy of central neural pathways to specific functional systems; be able to localize and name a CNS legion when presented with neurological symptoms, and appreciate higher cortical functions and how they relate to the practice of neurology. neuroscience
Автор: Ren-Jang Lin Название: RNA-Protein Complexes and Interactions ISBN: 1493935895 ISBN-13(EAN): 9781493935895 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Characterization of RNA-Protein Interactions: Lessons from Two RNA-Binding Proteins, SRSF1 and SRSF2
Lindsey Skrdlant and Ren-Jang Lin
2. Identification of mRNA-Interacting Factors by MS2-TRAP (MS2-Tagged RNA Affinity Purification)
Je-Hyun Yoon and Myriam Gorospe
3. Biotin-Streptavidin Affinity Purification of RNA-Protein Complexes Assembled In Vitro
Shuai Hou, Lei Shi, and Haixin Lei
4. Detecting RNA-Protein Interaction Using End-Labeled Biotinylated RNA Oligonucleotides and Immunoblotting
Xuexiu Zheng, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hana Jang, and Haihong Shen
5. Purification of RNA-Protein Splicing Complexes Using a Tagged Protein from In Vitro Splicing Reaction Mixture
Naoyuki Kataoka
6. Loading of Argonaute Protein with Small Duplex RNA in Cellular Extracts
Keith T. Gagnon
7. In Vitro Analysis of Ribonucleoprotein Complex Remodeling and Disassembly
Hua-Lin Zhou and Hua Lou
8. Single-Turnover Kinetics of Methyl Transfer to tRNA by Methyltransferases
Ya-Ming Hou
9. Purification and Functional Reconstitution of Box H/ACA Ribonucleoprotein Particles
Chao Huang, Guowei Wu, and Yi-Tao Yu
10. Northwestern Blot Analysis: Detecting RNA-Protein Interaction After Gel Separation of Protein Mixture
Shangbing Zang and Ren-Jang Lin
11. Measuring mRNA Translation by Polysome Profiling
Marek Kudla and Fedor V. Karginov
12. Genome-Wide Profiling of RNA-Protein Interactions Using CLIP-Seq
Cheryl Stork and Sika Zheng
13. Identification of Endogenous mRNA-Binding Proteins in Yeast Using Crosslinking and PolyA Enrichment
Sarah F. Mitchell and Roy Parker
14. Ribo-Proteomics Approach to Profile RNA-Protein and Protein-Protein Interaction Networks
Hsin-Sung Yeh, Jae-Woong Chang, and Jeongsik Yong
15. Detection of Protein-Protein Interaction Within an RNA-Protein Complex Via Unnatural-Amino-Acid-Mediated Photochemical Crosslinking
Fu-Lung Yeh, Luh Tung, and Tien-Hsien Chang
16. Evolution of Cell-Type-Specific RNA Aptamers Via Live Cell-Based SELEX
Jiehua Zhou and John J. Rossi
17. mCarts: Genome-Wide Prediction of Clustered Sequence Motifs as Binding Sites for RNA Binding Proteins
Sebastien M. Weyn-Vanhentenryck and Chaolin Zhang
18. Design
Автор: Kenneth C. Keiler Название: Bacterial Regulatory RNA ISBN: 1493959417 ISBN-13(EAN): 9781493959419 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) volume covers methods and techniques to identify regulatory RNAs, characterizing the function and expression of regulatory RNAs in bacterial cells, RNA structure prediction and interaction between regulatory RNAs and proteins.
Автор: Elliott Michael Название: Molecular Biology of RNA ISBN: 0199288372 ISBN-13(EAN): 9780199288373 Издательство: Oxford Academ Рейтинг: Цена: 6493.00 р. Наличие на складе: Поставка под заказ.
Описание: Molecular Biology of RNA provides a broad survey of RNA structure and function. Describing the life cycle of an RNA, it reveals how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond messenger RNA, including catalysts and regulatory molecules.
Автор: Michael R. Emmert-Buck; John W. Gillespie; Rodrigo Название: Dissecting the Molecular Anatomy of Tissue ISBN: 3642060331 ISBN-13(EAN): 9783642060335 Издательство: Springer Рейтинг: Цена: 29209.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book provides an updated overview of molecular analysis of human tissues, and the impact this analysis has on diagnosis and prognosis of human diseases.
Автор: Mathias Munschauer Название: High-Resolution Profiling of Protein-RNA Interactions ISBN: 3319162527 ISBN-13(EAN): 9783319162522 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universit?t Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.
Автор: Mathias Munschauer Название: High-Resolution Profiling of Protein-RNA Interactions ISBN: 3319368486 ISBN-13(EAN): 9783319368481 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel `protein occupancy profiling` technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders.
Автор: Frank J. Schmidt Название: RNA-RNA Interactions ISBN: 1493918958 ISBN-13(EAN): 9781493918959 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
In this volumeexpert researchers in the field detail many of the methods which are now commonly used to study RNA. These methods are presented as a guidebook to scientists who are experienced with RNA research and want to brush up on a new technique. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Thorough and intuitive, RNA-RNA Interactions: Methods and Protocols guides scientists investigating biological systems and studying RNA.
Автор: Frank J. Schmidt Название: RNA-RNA Interactions ISBN: 1493941615 ISBN-13(EAN): 9781493941612 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Identifying RNA Recombination Events and Non-covalent RNA-RNA Interactions with the Molecular Colony Technique
Helena V. Chetverina and Alexander B. Chetverin
2. RNA-directed Recombination of RNA in Vitro
Niles Lehman, Nilesh Vaidya, and Jessica A. M. Yeates
3. RNA-RNA Selex
B. Cho
4. Identification of Antisense RNA S0tem-loops that Inhibit RNA-protein Interactions using a Bacterial Reporter System
Kazuo Harada
5. Trans-activation of Large Ribozymes
Matthew B. Martin, Thomas L. Leeper, and Frank J. Schmidt
6. Native Purification and Labeling of RNA for Single Molecule Fluorescence Studies
Arlie J. Rinaldi, Krishna C. Suddala, and Nils G. Walter
7. Single Molecule Studies of RNA-RNA Interactions
Dongmei Yu, Peiwu Qin, and Peter V. Cornish
8. Modification Interference Analysis of the Ribosome
Simpson Joseph
9. Assessing Intermolecular RNA: RNA Interactions Within a Ribonucleoprotein Complex Using Heavy Metal Cleavage Mapping
Keith T. Gagnon and E. Stuart Maxwell
10. Monitoring RNA-RNA Interactions With Electrophoretic Mobility Shift Assays: Analysis Of Trna Binding To The T Box Riboswitch Antiterminator RNA
R. Anupam, S. Zhou, and J.V. Hines
11. Electrophoretic Mobility Shift Assay of RNA-RNA Complexes
Geunu Bak, Kook Han, Kwang-sun Kim, and Younghoon Lee
12. Structural Studies of a Double-stranded RNA from Trypanosome RNA Editing by
Small Angle X-ray Scattering
Angela Criswell and Blaine H.M. Mooers
13. Fusion RNAs in Crystallographic Studies of Double-stranded RNA from
Trypanosome RNA Editing
Blaine H.M. Mooers
Автор: Thomas Dandekar; P. Bengert; T. Dandekar; D. Ostar Название: RNA Motifs and Regulatory Elements ISBN: 364262586X ISBN-13(EAN): 9783642625862 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: RNA Motifs and Regulatory Elements is the new edition of the successful book, "Regulatory RNA".
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