This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Описание: Recent scientific advances have revolutionized cancer research and practice, creating a body of molecular biology information that is important to research scientists and clinical oncologists alike. Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer, 3rd Edition, keeps you up to date with all that’s new in this rapidly changing field. Derived from DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology – widely regarded as the definitive clinical reference in oncology – the third edition of this popular Primer provides a single-volume, highly focused reference on every important frontier in the molecular biology of cancer.
Compiles the knowledge and experience of leading scientists and clinicians in the field.
Provides separate chapters on each of the 18 most common cancer types, with state-of-the-art information on how molecular biology advances are impacting clinical practice.
Includes a thorough chapter on genetic counseling and genetic testing to help you navigate the challenges and ethical dilemmas of cancer genetics.
Covers key topics such as Hallmarks of Cancer, Precision Medicine in Oncology, Cancer Immunotherapy, Pharmacogenomics, and many more.
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Автор: Pecorino Lauren Название: Molecular Biology of Cancer ISBN: 0198717342 ISBN-13(EAN): 9780198717348 Издательство: Oxford Academ Рейтинг: Цена: 7126.00 р. Наличие на складе: Поставка под заказ.
Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers the most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear.
Автор: Pelengaris Название: The Molecular Biology of Cancer, 2nd Edition ISBN: 1118008812 ISBN-13(EAN): 9781118008812 Издательство: Wiley Рейтинг: Цена: 10306.00 р. 14723.00-30% Наличие на складе: Есть (1 шт.) Описание: The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.
Автор: Mendelsohn, John Название: The Molecular Basis of Cancer ISBN: 1455740667 ISBN-13(EAN): 9781455740666 Издательство: Elsevier Science Рейтинг: Цена: 25095.00 р. Наличие на складе: Поставка под заказ.
Описание: Arms you with the advances in the battle against cancer. This title explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease.
Автор: Georg F. Weber Название: Molecular Therapies of Cancer ISBN: 3319132776 ISBN-13(EAN): 9783319132778 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.
Автор: Giordano Название: Molecular Pathology of Gynecologic Cancer ISBN: 1588294536 ISBN-13(EAN): 9781588294531 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Focuses on molecular strategies for the treatment of gynecologic cancer. This work presents the hypothesis that cancer is a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. It also focuses on the model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, and more.
Автор: Coleman Название: Molecular Basis of Human Cancer.2001 ISBN: 0896036340 ISBN-13(EAN): 9780896036345 Издательство: Wiley Рейтинг: Цена: 16625.00 р. Наличие на складе: Поставка под заказ.
Описание: Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.
Автор: Piccart Название: Breast Cancer Management and Molecular Medicine ISBN: 3540282653 ISBN-13(EAN): 9783540282655 Издательство: Springer Рейтинг: Цена: 48913.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides an overview of the techniques, agents and approaches for breast cancer and its treatment. This book presents organ-specific approaches and their impact on the re-classification of breast cancer. It also addresses the integration of biological markers, technologies, diagnostic and therapeutic approaches into clinical trials and practice.
Автор: Augusto Villanueva Название: Resistance to Molecular Therapies for Hepatocellular Carcinoma ISBN: 3319561960 ISBN-13(EAN): 9783319561967 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance;
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