Автор: A.F. Casy; R.T. Parfitt Название: Opioid Analgesics ISBN: 1489905871 ISBN-13(EAN): 9781489905871 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.
Описание: Opioids and analgesics are members of a group of drugs used to relieve pain. They are used in combination with prescription and nonprescription pain relievers, and misuse is prevalent. This work helps pain medicine specialists and physicians in prescribing the appropriate drugs for pain therapy and for preventing misuse of the medication.
Автор: K. D. Rainsford; Michael Powanda Название: Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs ISBN: 0792387376 ISBN-13(EAN): 9780792387374 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Contains discussions on the central issues concerning the safety and efficacy of OTC analgesics and NSAIDs at the symposium held at the South San Francisco Conference Center (USA) on March 17, 1997. This book also includes the debate which followed the formal presentations.It is useful to general physicians, rheumatologists, and pharmacologists.
Автор: K. D. Rainsford; Michael Powanda Название: Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs ISBN: 9401060444 ISBN-13(EAN): 9789401060448 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the International Conference, San Francisco, CA, USA
Автор: Dalip J.S. Sirinathsinghji; Ray G. Hill Название: NMDA Antagonists as Potential Analgesic Drugs ISBN: 3764360119 ISBN-13(EAN): 9783764360115 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This book gives information on molecular biology, physiology and pharmacology of NMDA receptors.
Автор: Smith Howard S. Название: Opioid Therapy in the 21st Century ISBN: 0199844976 ISBN-13(EAN): 9780199844975 Издательство: Oxford Academ Рейтинг: Цена: 7522.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Opioid Therapy in the 21st Century, Second Edition provides clinicians with up-to-date, evidence-based information about appropriate opioid use, including the potential benefits and adverse affects of the therapy.
Автор: Ballantyne, Jane; Tauben, David J. Название: Expert Decision Making on Opioid Treatment ISBN: 0199768889 ISBN-13(EAN): 9780199768882 Издательство: Oxford Academ Рейтинг: Цена: 9662.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers expert, balanced, concise guidance on how clinicians can navigate a number of complex considerations to formulate a treatment plan for chronic pain that either includes or advisedly excludes opioids.
Автор: Annette M. Matthews; Jonathan C. Fellers Название: Treating Comorbid Opioid Use Disorder in Chronic Pain ISBN: 3319298615 ISBN-13(EAN): 9783319298610 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ГЇВїВЅ This in-depth text addresseshow to approach and treat the chronic pain patient struggling with problematicopioid use. The last part of the book addressestreating comorbid pain and opioid use disorder in different medical settings and thetreatment of co-occurring mental illnesses and substance abuse.
Автор: Santi M. Spampinato Название: Opioid Receptors ISBN: 1493955500 ISBN-13(EAN): 9781493955503 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Opioid Receptors: Methods and Protocols serves as a comprehensive guide to both key new techniques and established methods for the investigation of genetics, structural biology, transcription, and post-transcriptional events of opioid receptors. Other methods cover the cellular detection and trafficking of opioid receptors in vitro and in vivo. Procedures aimed to investigate signaling pathways modulated by opioid receptors and model systems to study opioid receptor-mediated functions are also included. Finally, methods to assay behavioral effects mediated by opioid receptors are described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective introductions, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Opioid Receptors: Methods and Protocols will help both experienced and new entrants in this field to carry out their experiments successfully and with new inspiration.
Автор: K.O. Stumpe; Karin Kraft; Alan I. Faden Название: Opioid Peptides and Blood Pressure Control ISBN: 3540189351 ISBN-13(EAN): 9783540189350 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A. , FADEN, K. KRAFr, and K. O. STUMPE Following the discovery of the pentapeptide enkephalins in 1975, a number of endogenous opioid peptides and opiate receptors have been identified. Endogenous opioids and opiate-receptor mechanisms have been implicated in a variety of regulat- ory and dysregulatory functions including analgesia, cardiovascular regulation, shock, hypertension, traumatic spinal cord and brain injury, stroke, immune func- tion, feeding behavior, diuresis, gastrointestinal motility, and respiratory control, among others. Over the past 10 years, many studies have demonstrated a relationship between endogenous opioids and the cardiovascular system under both homeostatic and pathophysiological conditions. Opioids and opiate receptors have been found in various cardioregulatory sites within the brain and spinal cord, as well as in peripheral tissues such as sympathetic ganglia, adrenal gland, and heart. Both endogenous opioids and exogenous opiates have been shown to produce potent cardiovascular effects following central nervous system or systemic administration. Opiate-receptor antagonists have been demonstrated to reverse hypotension from sepsis, hypo- volemia, and anaphylaxis; such studies have been used to infer activity of endogenous opioid systems in shock. Changes in tissue concentrations of endogenous opioids and or opiate receptors have been found after shock and hypertension, further implying a role for opioid systems in the etiology of these conditions. In addition, modification of opiate receptor regulation, receptor binding, or opioid metabolism has also been used to establish a potential role for endogenous opioid systems in cardiovascular control and dyscontrol.
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