Описание: This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in ?-helices but PrPSc are rich in ?-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Автор: Wen-Quan Zou; Pierluigi Gambetti Название: Prions and Diseases ISBN: 1489993975 ISBN-13(EAN): 9781489993977 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
Автор: Victoria A. Lawson Название: Prions ISBN: 1493972421 ISBN-13(EAN): 9781493972425 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details protocols on prion disease from multiple disciplines and highlights the contribution each discipline has made to the understanding of prion disease.
Автор: Douglas R.O. Morrison Название: Prions and Brain Diseases in Animals and Humans ISBN: 1489918981 ISBN-13(EAN): 9781489918987 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ARW held in Erice, Italy, August 19-23, 1996
Автор: Wen-Quan Zou; Pierluigi Gambetti Название: Prions and Diseases ISBN: 1489991425 ISBN-13(EAN): 9781489991423 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volume I highlights the association of cellular prion protein (PrPC) with copper and zinc; potential roles of PrPC in Alzheimer`s disease and cancers, infectious and pathogenic forms of PrP, yeast prions and their inheritable and structural traits and more.
Автор: Stanley B. Prusiner Название: Prions Prions Prions ISBN: 3642646409 ISBN-13(EAN): 9783642646409 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Straussler-Scheinker disease, and fatal familial insomnia.
Автор: Collinge Название: Prion Diseases.1997 ISBN: 0198547897 ISBN-13(EAN): 9780198547891 Издательство: Oxford Academ Цена: 2772.00 р. Наличие на складе: Поставка под заказ.
Описание: The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists, veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide an up-to-date and authoritative summary of the field.
Автор: Martin H. Groschup; Hans Kretzschmar Название: Prion Diseases ISBN: 3211835296 ISBN-13(EAN): 9783211835296 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive understanding of the biology of prion diseases is crucial for risk assessment as regards both humans and animals. To further the communication of the current knowledge and the exchange of diagnostic technologies in the scientific community, a symposium on the 'Characterization and Diagnosis of Prion Diseases' was held from September 23-25, 1999 in Tubingen, Germany. The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this Supplementum to Archives of Virology twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains. This selection attempts to reflect the current state of the art, but cannot possibly represent the whole spectrum of research in the prion field.
Автор: Martin H. Groschup; Hans Kretzschmar Название: Prion Diseases ISBN: 321183530X ISBN-13(EAN): 9783211835302 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Поставка под заказ.
Описание: Presents twenty-six invited speakers` data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
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